Rabbit anti phospho c-Jun [pS73]
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Catalog number
X2018P
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Price
Please ask
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Size
100uL
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Category
Primary Antibodies
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Long description
c-Jun is a 39 kDa member of the AP-1 family of leucine zipper transcription factors, formed bythe association of Fos proteins (c-Fos, FosB, Fra-1, Fra-2) or ATF proteins (ATF-2, ATF-a) with Jun proteins (c-Jun, JunB and JunD). Phosphorylation of serines 63 and 73 by c-Jun N-terminal kinase (JNK) activates c-Jun and thereby increases AP-1 transcriptional activity. Signals relayed by JNK through c-Jun regulate a range of cellular processes including cell proliferation, tumorigenesis, apoptosis and embryonic development. c-Jun can play seemingly opposite roles in cellular function depending on the cell type. In neuronal cells c-Jun has been shown to promote apoptosis, while in fibroblasts it has been shown to promote cell proliferation and protect against stress-induced apoptosis. Phosphorylation at serine 73 has also been shown to increase neurite outgrowth.
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Antibody come from
n/a
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Other description
Purified from rabbit serum by sequential epitope-specific chromatography. The antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated c-Jun. The final product is generated by affinity chromatography using a c-Jun-derived peptide that is phosphorylated at serine 73.
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Clone
Polyclonal
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Antigen antibody binding interaction
Rabbit anti phospho c-Jun [pS73] Antibody
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Antibody is raised in
Rabbit
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Antibody s reacts with
Mouse
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
Western Blot
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Antibody s suited for
Optimal concentration should be evaluated by serial dilutions.
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Storage
-20ºC
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Relevant references
no information yet
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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About
Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
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Gene target
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Short name
Rabbit anti phospho c-Jun [pS73]
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Technique
Rabbit, anti, antibody to
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Host
Rabbit, Rabbits
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Isotype
not specified
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Label
unlabeled
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Alternative name
production species: rabbit antibody to phosphorilated c-jun proto-oncogene [pS73]
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Alternative technique
rabbit-anti, antibodies
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Alternative to gene target
jun proto-oncogene, AP-1 and AP1 and c-Jun, JUN and IDBG-99221 and ENSG00000177606 and 3725, HMG box domain binding, nuclei, Jun and IDBG-164161 and ENSMUSG00000052684 and 16476, JUN and IDBG-638846 and ENSBTAG00000004037 and 280831
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MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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