Mouse anti Cytochrome P450 1A2

• Catalog number
  X2046M
• Price
  Please ask
• Size
  200 μg

• Category
  Primary Antibodies
• Long description
  P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. Several P450 enzymes have been classified by sequence similarities as members of the CYP1A and CYP2A subfamilies. NADPH cytochrome 450 reductase is a microsomal enzyme responsible for the transfer of electrons from NADPH to cytochrome P450 enzymes during the P450 catalytic cycle. NADPH cytochrome P450 reductase is localized to the endoplasmic reticulum where it is also able to transfer electrons to heme oxygenase and cytochrome 5. NADPH cytochrome P450 reductase is structurally related to two separate flavoprotein families, ferredoxin nucleotide reductase (FNR) and flavodoxin. Electron transfer of NADPH cytochrome P450 reductase requires the binding of two flavin cofactors, FAD and FMN, to the FNR and flavodoxin domains, respectively.
• Antibody come from
  Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the human ATIC protein and mouse myeloma Ag8563 cells. Sequence common in frog, fruit fly, rat and mouse.
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
• Clone
  3B8C1
• Antigen antibody binding interaction
  Mouse anti Cytochrome P450 1A2 Antibody
• Antibody is raised in
  Mouse
• Antibody s reacts with
  Human, Rat
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western Blot, Immunohistochemistry
• Antibody s suited for
  Antibody can be used for Western blotting (1-2 µg/ml) and immunohistochemistry on formalin-fixed, paraffin-embedded tissues (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  1. Bulock, K.G., et al. (2002). The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. J. Biol. Chem. 277(25):22168-22174._x000B__x000B_2. Marie, S., et al. (2004). AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. Am. J. Hum. Genet. 74(6):1276-1281.
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  Cytochrome   P450   1A2  
• Gene symbol
  CYP3A7, CYP24A1, CYP1A1, CYP51A1, CYP2D6
• Short name
  Mouse anti Cytochrome P450 1A2
• Technique
  Mouse, anti, antibody to, mouses
• Host
  mouse
• Isotype
  IgG1
• Label
  unlabeled
• Species
  Mouse, Mouses
• Alternative name
  Mouse antibody to Cytochrome P450 1A2
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:2640
• Gene
  CYP3A7
• Long gene name
  cytochrome P450 family 3 subfamily A member 7
• Synonyms gene name
  • cytochrome P450, subfamily IIIA, polypeptide 7
  • cytochrome P450, family 3, subfamily A, polypeptide 7
• Synonyms
  • CP37
  • P450-HFLA
• GenBank acession
  • AF315325
• Locus
  7q22.1
• Discovery year
  1992-09-14
• Entrez gene record
  1551
• Pubmed identfication
  • 2722762
• Classification
  • Cytochrome P450 family 3
• VEGA ID
  OTTHUMG00000156726
• Locus Specific Databases
  • PharmVar Human Cytochrome P450 (CYP) Allele Nomenclature

Gene info

• Identity
  HGNC:2602
• Gene
  CYP24A1
• Long gene name
  cytochrome P450 family 24 subfamily A member 1
• Synonyms gene
  • CYP24
• Synonyms gene name
  • cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)
  • cytochrome P450, family 24, subfamily A, polypeptide 1
• Synonyms
  • CP24
  • P450-CC24
• GenBank acession
  • U60669
• Locus
  20q13.2
• Discovery year
  1992-09-09
• Entrez gene record
  1591
• Classification
  • Cytochrome P450 family 24
• VEGA ID
  OTTHUMG00000032773

Gene info

• Identity
  HGNC:2595
• Gene
  CYP1A1
• Long gene name
  cytochrome P450 family 1 subfamily A member 1
• Synonyms gene
  • CYP1
• Synonyms gene name
  • cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
  • cytochrome P450, family 1, subfamily A, polypeptide 1
• Synonyms
  • P450DX
  • P1-450
  • P450-C
  • CP11
• GenBank acession
  • BC023019
• Locus
  15q24.1
• Discovery year
  1986-01-01
• Entrez gene record
  1543
• Pubmed identfication
  • 15128046
• RefSeq identity
  • NM_000499
• Classification
  • Cytochrome P450 family 1
• VEGA ID
  OTTHUMG00000142812
• Locus Specific Databases
  • PharmVar Human Cytochrome P450 (CYP) Allele Nomenclature
  • LRG_1262

Gene info

• Identity
  HGNC:2649
• Gene
  CYP51A1
• Long gene name
  cytochrome P450 family 51 subfamily A member 1
• Synonyms gene
  • CYP51
• Synonyms gene name
  • cytochrome P450, 51 (lanosterol 14-alpha-demethylase)
  • cytochrome P450, family 51, subfamily A, polypeptide 1
• Synonyms
  • CP51
  • CYPL1
  • P450L1
  • LDM
  • P450-14DM
• GenBank acession
  • U51685
• Locus
  7q21.2
• Discovery year
  1996-10-26
• Entrez gene record
  1595
• Pubmed identfication
  • 8975714
• Classification
  • Cytochrome P450 family 51
• VEGA ID
  OTTHUMG00000131131

Gene info

• Identity
  HGNC:2625
• Gene
  CYP2D6
• Long gene name
  cytochrome P450 family 2 subfamily D member 6
• Synonyms gene
  • CYP2DL1
  • CYP2D7P2
  • CYP2D7BP
  • CYP2D8P2
  • CYP2D7AP
• Synonyms gene name
  • cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6
  • cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2
  • cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2
  • cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2
  • cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2
  • cytochrome P450, family 2, subfamily D, polypeptide 6
• Synonyms
  • CPD6
  • P450-DB1
  • CYP2D
  • P450C2D
• GenBank acession
  • M20403
• Locus
  22q13.2
• Discovery year
  1992-04-07
• Entrez gene record
  1565
• Pubmed identfication
  • 8449513
• Classification
  • Cytochrome P450 family 2
• VEGA ID
  OTTHUMG00000150918
• Locus Specific Databases
  • PharmVar Human Cytochrome P450 (CYP) Allele Nomenclature
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_303

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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