Mouse anti CXCR4

• Catalog number
  X1895M
• Price
  Please ask
• Size
  500 μg

• Category
  Primary Antibodies
• Long description
  A receptor for the C-X-C chemokine CXCL12/SDF-1, CXCR4 transduces a signal by increasing the intracellular calcium ions level. It is involved in haematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus._x000B__x000B_Clone 12G5 has been shown to block infection by certain isolates of HIV-1 and HIV-2 and is specific for CXCR4 and does not react with IL8R-A, CCR1, CCR2b, CCR3, CCR4, and CCR5. CXCR4 is upregulated in response to activation of PBMCs for 3-5 days with PHA.
• Antibody come from
  Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with human recombinant IL-2 protein and NSO mouse myeloma cells.
• Other description
  Purified IgG in phosphate buffered saline, pH 7.4. Protein A/G Chromatography
• Clone
  12G5
• Antigen antibody binding interaction
  Mouse anti CXCR4 Antibody
• Antibody is raised in
  Mouse
• Antibody s reacts with
  Human, Monkey
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Immunohistochemistry, Immunocytochemistry,Flow Cytometry
• Antibody s suited for
  Antibody can be used for neutralization studies (inhibition of IL-2 binding to p55 receptor), dot blots and immunohistochemistry. Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  Rebollo, A., D. De Groote, M. Baudrihay, J. Theze, and D.L. Jankovic (1992) Immunochemical characterization of antigenic domains on human IL-2: spatially distinct epitopes are associated with binding to the p55 and p70 subunits of IL-2 receptor. Mol. Immunol. 29(1):119-130.
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  CXCR4  
• Gene symbol
  CXCR4
• Short name
  Mouse anti CXCR4
• Technique
  Mouse, anti, antibody to, mouses
• Host
  mouse
• Isotype
  IgG1
• Label
  unlabeled
• Species
  Mouse, Mouses
• Alternative name
  Mouse antibody to chemokine (C-X-C motif) receptor 4
• Alternative technique
  murine, antibodies
• Alternative to gene target
  chemokine (C-X-C motif) receptor 4, CD184 and D2S201E and FB22 and HM89 and HSY3RR and LAP-3 and LAP3 and LCR1 and LESTR and NPY3R and NPYR and NPYRL and NPYY3R and WHIM, CXCR4 and IDBG-71032 and ENSG00000121966 and 7852, ubiquitin binding, Cell surfaces, Cxcr4 and IDBG-189999 and ENSMUSG00000045382 and 12767, CXCR4 and IDBG-642187 and ENSBTAG00000001060 and 281736

Gene info

• Identity
  HGNC:2561
• Gene
  CXCR4
• Long gene name
  C-X-C motif chemokine receptor 4
• Synonyms gene name
  • chemokine (C-X-C motif), receptor 4 (fusin)
  • chemokine (C-X-C motif) receptor 4
• Synonyms
  • LESTR
  • NPY3R
  • HM89
  • NPYY3R
  • D2S201E
  • fusin
  • HSY3RR
  • NPYR
  • CD184
• GenBank acession
  • AF005058
• Locus
  2q22.1
• Discovery year
  1998-09-17
• Entrez gene record
  7852
• Pubmed identfication
  • 9599023
  • 9379028
• Classification
  • C-X-C motif chemokine receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000153583
• Locus Specific Databases
  • CXCR4base: Mutation registry for WHIM syndrome (warts, hypogammaglobulinemia, immunodeficiency, and myelokathexis)
  • LRG_51

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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