VEGFR 3, Vascular endothelial growth factor receptor 3

• Catalog number
  AS10 1574
• Price
  Please ask
• Size
  0.2 mg

• Available ordering format
  Liquid in 0.9% NaCl, 0.02% sodium azide
• Immunogen
  KLH-conjugated synthetic peptide: LASEEFEQIESRHRQESGFR, corresponding to aa 1278-1297 of human VEGF Receptor 3. Accesion number Q86W07.
• Raised in
  Chicken
• Clonality
  Polyclonal
• Clone
  Polyclonal
• Purification
  Total IgY
• How to reconstitute
  See included datasheet or contact our support service
• Storage condition
  4 to 8°C
• Verified applications
  ELISA (ELISA), immunohistochemistry (IHC)
• Connected products
  AS10 1571 | Anti-VEGFR1 | Vascular endothelial growth factor receptor 1secondary antibodies
• Recommended dilutions for use
  1:1000 (ELISA), 1:10 000 (IHC)
• Molecular weight expected аpparent
  152.8 kDa
• Verified reactivity
  human
• Possible reactivity
  macaque, rat, mouse
• No reactivity
  no confirmed exceptions from predicted reactivity known at the moment
• Supplementary information
  Direct ELISA has been done on peptide used to elicit this antibody. IHC has been done on paraffin embedded sections.
• References
  to be added when available
• Scientific context
  VEGFR3 | Vascular endothelial growth factor receptor 3 are receptors for vascular endothelial growth factor (VEGF). (VEGF) is an important signaling protein involved in both vasculogenesis (the formation of the circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). It have effects on a limited number of other cell types (e.g. stimulation monocyte/macrophage migration).
• Notes
  None
• Protein number
  Q86W07
• TAIR number
  Refer to NCBI
• Hyperlink
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  VEGFR   Vascular   endothelial   growth   factor   receptor  
• Gene symbol
  FLT4, KDR
• Short name
  VEGFR 3, Vascular endothelial growth factor receptor 3
• Alternative name
  VEGFR 3, Vascular endothelial growth factor receptor 3
• Tissue
  vascular

Gene info

• Identity
  HGNC:3767
• Gene
  FLT4
• Long gene name
  fms related receptor tyrosine kinase 4
• Synonyms gene name
  • fms-related tyrosine kinase 4
  • fms related tyrosine kinase 4
• Synonyms
  • VEGFR3
  • PCL
  • VEGFR-3
• Synonyms name
  • vascular endothelial growth factor receptor 3
  • VEGF receptor-3
  • Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
  • primary congenital lymphedema
• GenBank acession
  • X68203
• Locus
  5q35.3
• Discovery year
  1991-10-25
• Entrez gene record
  2324
• Pubmed identfication
  • 1319394
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000130931

Gene info

• Identity
  HGNC:6307
• Gene
  KDR
• Long gene name
  kinase insert domain receptor
• Synonyms gene name
  • kinase insert domain receptor (a type III receptor tyrosine kinase)
• Synonyms
  • FLK1
  • VEGFR
  • VEGFR2
  • CD309
• Synonyms name
  • vascular endothelial growth factor receptor 2
  • fetal liver kinase 1
• GenBank acession
  • AF035121
• Locus
  4q12
• Discovery year
  1991-07-10
• Entrez gene record
  3791
• Pubmed identfication
  • 1417831
• Classification
  • Receptor tyrosine kinases
  • CD molecules
  • I-set domain containing
  • V-set domain containing
• VEGA ID
  OTTHUMG00000128734
• Locus Specific Databases
  • The Globin Gene Server
  • LRG_1198

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