Tyrosine Kinase Receptor Antibody, ALEXA FLUOR 647

  • Catalog number
    bs-0192R-A647
  • Product name
    Tyrosine Kinase Receptor Antibody, ALEXA FLUOR 647
  • Size
    100ul
  • Price
    392.84
  • Supplier
    Bioss Primary Conjugated Antibodies. ALEXA FLUOR
  • Long name
    Tyrosine Kinase Receptor Antibody, ALEXA FLUOR 647 Conjugated
  • Also known as
    Anti-Trk A + B + C PAb ALEXA FLUOR 647
  • Category
    Conjugated Primary Antibodies
  • Conjugated with
    ALEXA FLUOR® 647
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    Trk A + B + C
  • Specificity
    This is a highly specific antibody against Trk A + B + C.
  • Modification
    Unmodified
  • Modification Site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Immunogen range
    640-676/796
  • Subcellular location
    Cytoplasm
  • Source
    This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Trk A
  • Gene ID Number
    4914
  • Swiss Prot
    P04629
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Cross-reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen
    Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
  • Purification
    Purified by Protein A.
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission
    650nm/665nm
  • Synonyms
    MTC; TRK; TRK1; TRKA; Trk-A; p14-TrkA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; gp14trk; NTRK1
  • group_crc32
    1270245574
  • Properties
    For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Tyrosine Kinase Receptor Antibody, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugation
    Alexa Fluor, ALEXA FLUOR 647
  • Description
    The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • French translation
    anticorps
  • Gene target
  • Short name
    Tyrosine Kinase Receptor Antibody,
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Label
    ALEXA FLUOR 647
  • Alternative name
    Tyrosine phosphorylation catalyst Receptor (Antibody to), ALEXA FLUOR 647
  • Alternative technique
    antibodies
1. Gene info
  • Identity
  • Gene
  • Long gene name
    leukocyte receptor tyrosine kinase
  • Synonyms gene name
    • leukocyte tyrosine kinase
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1991-06-28
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Receptor Tyrosine Kinases
  • Havana BLAST/BLAT
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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