TrkB Antibody
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Catalog numberR31270
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PricePlease ask
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Size0.1mg
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CategoryAntibody
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Concentration0.5mg/ml if reconstituted with 0.2ml sterile DI water
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FormAntigen affinity purified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenTrkB
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB
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Recommended dilutionsWestern blot: 0.5-1ug/ml
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NotesThe stated application concentrations are suggested starting amounts. Titration of the TrkB antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Intented useThis TrkB antibodyis to be used only for research purposes and not for diagnostics..
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UniprotQ16620
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PurityAntigen affinity
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DescriptionNeurotrophic tyrosine kinase receptor type 2 , also known as BDNF/NT-3 growth factors receptor, is a protein that in humans is encoded by the NTRK2 gene. TrkB is part of the large family of receptor tyrosine kinases. This gene is mapped to 9q21.33. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
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ImmunogenAn amino acid sequence from the N-terminus of human TrkB (EIFIANQKRLEIINEDDVEAY) was used as the immunogen for this TrkB antibody.
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StorageAfter reconstitution, the TrkB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolNTRK2
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Short nameAnti-TrkB
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibodies to TrkB
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameneurotrophic receptor tyrosine kinase 2
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Synonyms gene name
- neurotrophic tyrosine kinase, receptor, type 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1991-07-18
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Entrez gene record
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Pubmed identfication
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Classification
- Receptor tyrosine kinases
- I-set domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data