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TAP2 Antibody, Cy5 Conjugated

  • Catalog number
    bs-2374R-Cy5
  • Product name
    TAP2 Antibody, Cy5 Conjugated
  • Size
    0.1ml
  • Price
    350EUR
  • Supplier
    Bioss Primary Conjugated Antibodies
  • Ask
  • Clonality
    Polyclonal
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Antigen background
    TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding.
  • Modification site
    None
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Long name
    TAP2 Polyclonal Antibody, Cy5 Conjugated
  • Subcellular location
    Cytoplasm
  • Synonyms
    Uncharacterized protein C9orf172; C9orf172
  • Gene ID number
    389813
  • Recommended dilutions
    FCM(1:20-100), IF(IHC-P)(1:50-200)
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Conjugation
    Cy5
  • Modification
    Unmodified
  • Category
    Conjugated Primary Antibodies
  • Source
    KLH conjugated synthetic peptide derived from human TAP2
  • Swiss Prot
    C9J069
  • Specificity
    This is a highly specific antibody against TAP2/ABCB3.
  • Tested applications
    FCM, IF(IHC-P)
  • Clone
    Polyclonal antibody
  • Crossreactivity
    Human, Mouse, Rat
  • Concentration
    1ug per 1ul
  • Target Antigen
    TAP2/ABCB3
  • Excitation Emission
    625,650nm/670nm
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
  • Additional conjugation
    Cy5.5
  • Gene target
  • Short name
    TAP2 Antibody, Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
    Cy5
  • Alternative name
    Uncharacterized protein (Antibody to), cyanine 5 coupled
  • Alternative technique
    antibodies
  • Alternative to gene target
    Uncharacterized protein, TAP2 and IDBG-403192 and ENSG00000250264 and, this GO :0002481 and antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent and biological process this GO :0002485 and antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent and biological process this GO :0002489 and antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent and biological process this GO :0002504 and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II and biological process this GO :0002591 and positive regulation of antigen processing and presentation of peptide antigen via MHC class I and biological process this GO :0005215 and transporter activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0006200 and ATP catabolic process and biological process this GO :0006810 and transport and biological process this GO :0006955 and immune response and biological process this GO :0015197 and peptide transporter activity and molecular function this GO :0015833 and peptide transport and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016887 and ATPase activity and molecular function this GO :0019882 and antigen processing and presentation and biological process this GO :0042613 and MHC class II protein complex and cellular component this GO :0042626 and ATPase activity, coupled to transmembrane movement of substances and molecular function this GO :0055085 and transmembrane transport and biological process, ATPase activity, this GO :0005215: transporter activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0015197: peptide transporter activity and also this GO :0016887: ATPase activity and also this GO :0042626: ATPase activity, coupled to transmembrane movement of substances, this GO :0005215: transporter activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0015197: peptide transporter activity, this GO :0016887: ATPase activity, this GO :0042626: ATPase activity, coupled to transmembrane movement of substances, Plasma membranes
  • Ask
1. Gene info
MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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