SIRT2 Antibody

• Catalog number
  R31579
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  SIRT2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting points. Titration of the SIRT2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This SIRT2 antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  22933
• Purity
  Antigen affinity
• Description
  Sirtuin 2 is a predominantly cytoplasmic protein that colocalizes with microtubules. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT2 is mapped to 19q13.2. It is able to cause radioactivity to be transferred from (32P) NAD to bovine serum albumin (BSA). According to researches, it can act as a tubulin deacetylase. SIRT2 was found to deacetylate lys40 of alpha-tubulin both in vitro and in vivo. It is also a regulator of mitotic progression that acts downstream from CDC14B in a pathway regulating mitotic exit or subsequent cytokinesis. Additionally, SIRT2 is an important regulator of programmed necrosis.
• Immunogen
  Amino acids 165-187 (YTQNIDTLERIAGLEQEDLVEAH-human) were used as the immunogen for this SIRT2 antibody.
• Storage
  After reconstitution, the SIRT2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SIRT2  
• Gene symbol
  SIRT2
• Short name
  Anti-SIRT2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to SIRT2
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10886
• Gene
  SIRT2
• Long gene name
  sirtuin 2
• Synonyms gene
  • SIR2L
• Synonyms gene name
  • sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2
  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
• GenBank acession
  • AF083107
• Locus
  19q13.2
• Discovery year
  1998-10-14
• Entrez gene record
  22933
• Pubmed identfication
  • 10393250
  • 10381378
• Classification
  • Sirtuins
• VEGA ID
  OTTHUMG00000150480

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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