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Rb/P105 RB (Thr821) Antibody, Cy7 Conjugated

  • Catalog number
    bs-3452R-Cy7
  • Product name
    Rb/P105 RB (Thr821) Antibody, Cy7 Conjugated
  • Size
    0.1ml
  • Price
    368EUR
  • Supplier
    Bioss Primary Conjugated Antibodies
  • Ask
  • Clonality
    Polyclonal
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Antigen background
    Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
  • Modification site
    Thr821
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Long name
    Rb/P105 RB (Thr821) Polyclonal Antibody, Cy7 Conjugated
  • Synonyms
    OSRC; P105 RB; P105RB; PP105; PP110; pRb; RB 1; RB1; RB1 protein; Retinoblastoma 1 including osteosarcoma; Retinoblastoma 1; Retinoblastoma associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene; Including osteosarcoma; RB_HUMAN.
  • Gene ID number
    5925
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Conjugation
    Cy7
  • Modification
    Phosphorylation
  • Category
    Conjugated Primary Antibodies
  • Source
    KLH conjugated synthetic phosphopeptide derived from human Retinoblastoma associated protein around the phosphorylation site of Thr821
  • Specificity
    This is a highly specific antibody against Rb/P105 RB Thr821.
  • Tested applications
    IF(IHC-P)
  • Clone
    Polyclonal antibody
  • Crossreactivity
    Human, Mouse, Rat
  • Concentration
    1ug per 1ul
  • Target Antigen
    Rb/P105 RB Thr821
  • Excitation Emission
    743nm/767nm
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugated
    These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
  • Additional conjugation
    Cy7
  • Gene target
  • Short name
    Rb/P105 RB (Thr821) Antibody, Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
    Cy7
  • Alternative name
    Rb/P105 RB (Thr821) (Antibody to), cyanine 7 coupled
  • Alternative technique
    antibodies
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MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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