HSC70 Antibody / HSPA8

  • Catalog number
  • Product name
    HSC70 Antibody / HSPA8
  • Size
  • Price
  • Supplier
    NJS poly
  • Category
  • Concentration
    0.5mg/ml if reconstituted with 0.2ml sterile DI water
  • Form
    Antigen affinity purified
  • Conjugation
  • Clone
    Polyclonal antibody
  • Recognised antigen
    HSC70 / HSPA8
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Species reactivity
    Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    WB, IHC-P
  • Recommended dilutions
    Western blot: 0.1-0.5ug/ml,IHC (Paraffin): 0.5-1ug/ml
  • Notes
    Optimal dilution of the HSC70 antibody should be determined by the researcher.
  • Intented use
    This HSC70 antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot #
  • Purity
    Antigen affinity
  • Description
    HSPA8 (heat shock 70kDa protein 8) also known as HSC70, HSC71, HSP73, HSPA10, FORMERLY, LAP1 or LPS-ASSOCIATED PROTEIN 1, is a heat shock protein that in humans is encoded by the HSPA8 gene. The HSPA8 gene contains 9 exons and spans 5 kb. The deduced HSPA8 protein has 646 amino acids and a predicted molecular mass of 70,899 Da. And the HSPA8 gene is mapped on 11q24.1. HSPA8 plays an important role in cells by transiently associating with nascent polypeptides to facilitate correct folding. HSP73 also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Rapid decay involves AU-rich binding protein AUF1, which complexes with heat-shock proteins HSC70 and HSP70, translation initiation factor EIF4G, and poly (A)-binding protein. In the absence of Il3, Hsc70 formed a complex with Hsp40 and Hip, and this complex, in association with Eif4g and Pabp, formed a high-stability complex with Bim mRNA that protected it from ribonucleases.
  • Immunogen
    Amino acids 520-614 of human HSPA8/HSC70 were used as the immunogen for the HSC70 antibody.
  • Storage
    After reconstitution, the HSC70 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
  • group_crc32
  • Properties
    If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
  • Gene target
    HSC70 / HSPA8 
  • Short name
    HSC70 Antibody / HSPA8
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative name
    HSC70 (Antibody to) / HSPA8
  • Alternative technique
1. Gene info
  • Identity
  • Gene
  • Long gene name
    heat shock protein family A (Hsp70) member 8
  • Synonyms gene
  • Synonyms gene name
    • heat shock 70kD protein 8
    • heat shock 70kDa protein 8
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Heat shock 70kDa proteins
    • NineTeen complex
  • Havana BLAST/BLAT
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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