ERK1 + ERK2 Antibody, Cy7 Conjugated
#
-
Catalog numberbs-0022R-Cy7
-
Price:
-
Size0.1ml
-
-
Long nameERK1 + ERK2 Polyclonal Antibody, Cy7 Conjugated
-
CategoryConjugated Primary Antibodies
-
ConjugationCy7
-
Host OrganismRabbit (Oryctolagus cuniculus)
-
Target AntigenERK1 + ERK2
-
SpecificityThis is a highly specific antibody against ERK1 + ERK2.
-
ModificationUnmodified
-
Modification siteNone
-
ClonalityPolyclonal
-
ClonePolyclonal antibody
-
Concentration1ug per 1ul
-
Immunogen_range330-358/358
-
Subcellular locationCytoplasm, Nucleus
-
SourceKLH conjugated synthetic peptide derived from mouse ERK2
-
Gene ID number26413
-
Swiss ProtP63085
-
Tested applicationsIF(IHC-P)
-
Recommended dilutionsIF(IHC-P)(1:50-200)
-
CrossreactivityHuman, Mouse, Rat
-
Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
-
Antigen backgroundSerine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis.
-
Purification methodThis antibody was purified via Protein A.
-
Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
-
Excitation Emission743nm/767nm
-
SynonymsMitogen-activated protein kinase 1; MAP kinase 1; MAPK 1; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; Mapk1; Erk2; Mapk; Prkm1
-
PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
-
Additional conjugationCy7
-
French translationanticorps
-
Gene target
-
Gene symbolMAPK3, MAPK1
-
Short nameAnti-ERK1 + ERK2
-
TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
-
IsotypeImmunoglobulin G (IgG)
-
LabelCy7
-
Alternative nameAnti-ERK1 + ERK2 PAb Cy7
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namemitogen-activated protein kinase 3
-
Synonyms gene
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1993-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Mitogen-activated protein kinases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemitogen-activated protein kinase 1
-
Synonyms gene
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1993-11-05
-
Entrez gene record
-
Classification
- Mitogen-activated protein kinases
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data