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DAPK1 Antibody, Cy5.5 Conjugated

  • Long name
    DAPK1 Polyclonal Antibody, Cy5.5 Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
    Cy5.5
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    DAPK1
  • Specificity
    This is a highly specific antibody against DAPK1.
  • Modification
    Unmodified
  • Modification site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Immunogen_range
    1360-1410/1430
  • Subcellular location
    Cytoplasm
  • Source
    KLH conjugated synthetic peptide derived from human DAPK1
  • Gene ID number
    1612
  • Swiss Prot
    P53355
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-133 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. Isoform 2 cannot induce apoptosis but can induce membrane blebbing.
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
    675nm/694nm
  • Synonyms
    DAPK; Death-associated protein kinase 1; DAP kinase 1; DAPK1
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
  • Additional conjugation
    Cy5.5, Cy5.5
  • Conjugated
    These antibodies are excite for emission at 678nm and detected at a 694 nm wavelengths.
  • French translation
    anticorps
  • Gene target
  • Short name
    DAPK1 Antibody, Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
    Cy5.5
  • Alternative name
    death-associated protein kinase 1 (Antibody to), cyanine 5.5 coupled
  • Alternative technique
    antibodies
  • Alternative to gene target
    death-associated protein kinase 1, DAPK, DAPK1 and IDBG-74918 and ENSG00000196730 and 1612, this GO :0003824 and catalytic activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004683 and calmodulin-dependent protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005516 and calmodulin binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0009103 and lipopolysaccharide biosynthetic process and biological process this GO :0010506 and regulation of autophagy and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, transferring phosphorus-containing groups and molecular function this GO :0016773 and phosphotransferase activity, alcohol group as acceptor and molecular function this GO :0017148 and negative regulation of translation and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0071346 and cellular response to interferon-gamma and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :1902042 and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2000310 and regulation of N-methyl-D-aspartate selective glutamate receptor activity and biological process, transferase activity, this GO :0003824: catalytic activity and also this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004683: calmodulin-dependent protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005516: calmodulin binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, transferring phosphorus-containing groups and also this GO :0016773: phosphotransferase activity, alcohol group as acceptor and also this GO :0042802: identical protein binding, this GO :0003824: catalytic activity, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004683: calmodulin-dependent protein kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005516: calmodulin binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, transferring phosphorus-containing groups, this GO :0016773: phosphotransferase activity, alcohol group as acceptor, this GO :0042802: identical protein binding, Plasma membranes, Dapk1 and IDBG-159357 and ENSMUSG00000021559 and 69635, DAPK1 and IDBG-636344 and ENSBTAG00000000738 and 540873
MESH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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