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CD31 Antibody, FITC Conjugated

  • Catalog number
    bs-0468R-FITC
  • Product name
    CD31 Antibody, FITC Conjugated
  • Size
    0.1ml
  • Price
    333EUR
  • Supplier
    Bioss Primary Conjugated Antibodies
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  • Clonality
    Polyclonal
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Antigen background
    Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-69 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
  • Modification site
    None
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Long name
    CD31 Polyclonal Antibody, FITC Conjugated
  • Subcellular location
    Cytoplasm
  • Synonyms
    CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM; Platelet endothelial cell adhesion molecule; PECAM1
  • Gene ID number
    5175
  • Recommended dilutions
    FCM(1:20-100), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Conjugation
    FITC
  • Modification
    Unmodified
  • Category
    Conjugated Primary Antibodies
  • Source
    KLH conjugated synthetic peptide derived from mouse CD31
  • Swiss Prot
    P16284
  • Specificity
    This is a highly specific antibody against CD31.
  • Tested applications
    FCM, IF(IHC-P), IF(ICC)
  • Clone
    Polyclonal antibody
  • Crossreactivity
    Human, Mouse, Rat, Dog
  • Concentration
    1ug per 1ul
  • Target Antigen
    CD31
  • Immunogen_range
    621-650/738
  • Excitation Emission
    494nm/518nm
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
  • Additional conjugation
    Anti-FITC Antibody
  • Gene target
  • Short name
    CD31 Antibody, FITC Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
  • Label
    FITC
  • Alternative name
    CD31 (Antibody to), fluorecein coupled
  • Alternative technique
    antibodies
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MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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