Bak Antibody

• Catalog number
  F42652-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Bak
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  IHC, WB, ELISA
• Recommended dilutions
  IHC (Paraffin): 1:50-1:100,Western blot: 1:1000
• Notes
  Titration of the Bak antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Bak antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q16611
• Purity
  Antigen affinity
• Description
  BAK belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAK localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
• Immunogen
  A portion of amino acids 56-91 from the human protein was used as the immunogen for this Bak antibody.
• Storage
  Aliquot the Bak antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Bak  
• Gene symbol
  BAK1
• Short name
  Anti-Bak
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to Bak
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:949
• Gene
  BAK1
• Long gene name
  BCL2 antagonist/killer 1
• Synonyms gene
  • CDN1
• Synonyms gene name
  • BCL2-antagonist/killer 1
• Synonyms
  • BCL2L7
  • BAK
• GenBank acession
  • U23765
• Locus
  6p21.31
• Discovery year
  1997-10-09
• Entrez gene record
  578
• Pubmed identfication
  • 7715730
  • 7715731
• RefSeq identity
  • NM_001188
• Classification
  • BCL2 family
• VEGA ID
  OTTHUMG00000014530

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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