Anti-LIMK1(Thr508)/LIMK2(Thr505), ALEXA Fluor 594

• Catalog number
  GENTObs-3247R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  LIMK1 Thr508/LIMK2 Thr505
• Specificity
  This antibody reacts specifically with LIMK1(Thr508)/LIMK2(Thr505)
• Modification
  Phosphorylation
• Modification site
  Thr505
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  N/A
• Antigen Source
  KLH conjugated synthetic phosphopeptide derived from human LIMK1 and LIMK2 around the phosphorylation site of Thr508 and Thr505
• Gene ID
  3984
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  LIMK1 is a protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. LIMK1 may be involved in brain development; it is highly expressed in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  LIMK1Thr508; EC 2.7.11.1; LIM domain kinase 1; LIM mot-containing protein kinase; LIMK; LIMK-1; LIMK2; LIMK-2; LIM domain kinase 2; LIMK1_HUMAN.
• Also known as
  LIMK1(Thr508)/LIMK2(Thr505) Antibody
• Other name
  Anti-LIMK1(Thr508)/LIMK2(Thr505)
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.

• Gene target
  LIMK1   Thr508   LIMK2   Thr505  
• Gene symbol
  LIMK2, LIMK1
• Short name
  Anti-LIMK1(Thr508)/LIMK2(Thr505)
• Technique
  anti-, anti, antibody to, antibodies
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  LIMK1(Thr508)/LIMK2(Thr505) Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6614
• Gene
  LIMK2
• Long gene name
  LIM domain kinase 2
• GenBank acession
  • D45906
• Locus
  22q12.2
• Discovery year
  1997-08-28
• Entrez gene record
  3985
• Pubmed identfication
  • 8537403
  • 10591208
• RefSeq identity
  • NM_016733
• Classification
  • PDZ domain containing
  • LIMK/TESK kinase family
  • LIM domain containing
• VEGA ID
  OTTHUMG00000151251

Gene info

• Identity
  HGNC:6613
• Gene
  LIMK1
• Long gene name
  LIM domain kinase 1
• Synonyms
  • LIMK
• GenBank acession
  • D26309
• Locus
  7q11.23
• Discovery year
  1996-03-14
• Entrez gene record
  3984
• Pubmed identfication
  • 8673124
  • 8812460
• RefSeq identity
  • NM_002314
• Classification
  • LIM domain containing
  • PDZ domain containing
  • LIMK/TESK kinase family
• VEGA ID
  OTTHUMG00000023448

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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