anti-ICAD Antibody

• Catalog number
  2003
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  ICAD Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which was cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF was identified as a DNase inhibitor designated ICAD, for inhibitor of caspase-activated DNase. Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is the hallmark of apoptotic cell death.
• Gene names
  ICAD Antibody: ICAD, DFF35, Dff45, ICAD-L, ICAD-S, A330085O09Rik, Icad, DNA fragmentation factor subunit alpha, DNA fragmentation factor 45 kDa subunit, DFF-45
• Antibodie s label
  unlabelled serum
• Purity
  ICAD Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  ICAD antibody was made against a 20 amino acid peptide near the carboxy terminus of mouse ICAD.
• Immuno application
  ELISA, Western Blot
• Antibody advice
  ICAD antibody can be used for detection of of ICAD by Western blot at 1:1000 dilution. A 45 kDa band can be detected.
• Suspention pH azide
  ICAD Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  ICAD antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Mouse
• Omim nr
  9087146
• Ncbi nr
  O54786
• KDa
  45 kDa
• Vial with antibody
  in solution
• NCBI GENE nr
  13347
• GENE symbol
  Dffa
• Antigene name
  DNA fragmentation factor, alpha subunit
• Source
  Mus musculus
• Protein nr
  O54786
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ICAD  
• Gene symbol
  DFFA
• Short name
  anti-ICAD Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toICAD (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2772
• Gene
  DFFA
• Long gene name
  DNA fragmentation factor subunit alpha
• Synonyms gene name
  • DNA fragmentation factor, 45 kD, alpha polypeptide
  • DNA fragmentation factor, 45kDa, alpha polypeptide
• Synonyms
  • DFF-45
  • DFF45
  • ICAD
  • DFF1
• Synonyms name
  • DNA fragmentation factor, 45 kD, alpha subunit
• GenBank acession
  • AF087573
• Locus
  1p36.22
• Discovery year
  1997-10-27
• Entrez gene record
  1676
• Pubmed identfication
  • 9605855
  • 9108473
• RefSeq identity
  • NM_004401
• VEGA ID
  OTTHUMG00000001909

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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