anti-Glial Fibrillary Acidic Protein Antibody

• Catalog number
  50-268
• Price
  Please ask
• Size
  0.1 mL

• Gene info
  Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10 nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers.
• Gene names
  GFAP
• Antibodie s label
  unlabelled serum
• Purity
  Total IgY fraction
• Ab raised in
  Chicken
• Type
  Polyclonal
• Spicific to
  Specific for the ~50kDa GFAP protein. A lower band at ~45kDa is a proteolytic fragment derived from the GFAP molecule.
• Antigen
  Recombinant and purified bovine GFAP.
• Immuno application
  Western Blot, immuno-histo-chemistry
• Keep at
  Glial Fibrillary Acidic Protein antibody can be stored at -20 grades C and is stable at -20 grades C for at least 1 year.
• Works with
  Human, Mouse, Rat
• Omim nr
  143811396
• Ncbi nr
  Q28115
• KDa
  50
• Vial with antibody
  in solution
• NCBI GENE nr
  281189
• GENE symbol
  GFAP
• Antigene name
  glial fibrillary acidic protein
• Source
  Bos taurus
• Protein nr
  Q28115
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Glial   Fibrillary   Acidic   Protein  
• Gene symbol
  GFAP
• Short name
  anti-Glial Fibrillary Acidic Protein Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toGlial Fibrillary Acidic Protein (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4235
• Gene
  GFAP
• Long gene name
  glial fibrillary acidic protein
• Synonyms
  • FLJ45472
• Synonyms name
  • intermediate filament protein
• GenBank acession
  • S40719
• Locus
  17q21.31
• Discovery year
  1989-12-07
• Entrez gene record
  2670
• Pubmed identfication
  • 9693047
• RefSeq identity
  • NM_002055
• Classification
  • Intermediate filaments Type III
• VEGA ID
  OTTHUMG00000179866

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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