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AIF Antibody, Cy3 Conjugated

  • Catalog number
    bs-0037R-Cy3
  • Product name
    AIF Antibody, Cy3 Conjugated
  • Size
    0.1ml
  • Price
    350EUR
  • Supplier
    Bioss Primary Conjugated Antibodies
  • Ask
  • Clonality
    Polyclonal
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Antigen background
    Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
  • Modification site
    None
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Long name
    AIF Polyclonal Antibody, Cy3 Conjugated
  • Subcellular location
    Cytoplasm, Mitochondrion
  • Synonyms
    AIF; CMT2D; CMTX4; COWCK; NADMR; NAMSD; PDCD8; COXPD6; Apoptosis-inducing factor 1, mitochondrial; Programmed cell death protein 8; AIFM1
  • Gene ID number
    9131
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Conjugation
    Cy3
  • Modification
    Unmodified
  • Category
    Conjugated Primary Antibodies
  • Source
    KLH conjugated synthetic peptide derived from human AIF
  • Swiss Prot
    O95831
  • Specificity
    This is a highly specific antibody against AIF.
  • Tested applications
    IF(IHC-P)
  • Clone
    Polyclonal antibody
  • Crossreactivity
    Human, Mouse, Rat, Pig
  • Concentration
    1ug per 1ul
  • Target Antigen
    AIF
  • Immunogen_range
    130-180/613
  • Excitation Emission
    512,550nm/570,615nm
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the AIF Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
  • Additional conjugation
    cy3 conjugation kit
  • Gene target
  • Short name
    AIF Antibody, Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
    Cy3
  • Alternative name
    AIF (Antibody to), cyanine 3 coupled
  • Alternative technique
    antibodies
  • Ask
1. Gene info
  • Identity
  • Gene
  • Long gene name
    apoptosis inducing factor mitochondria associated 1
  • Synonyms gene
  • Synonyms gene name
    • programmed cell death 8 (apoptosis-inducing factor)
    • neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome)
    • apoptosis-inducing factor, mitochondrion-associated, 1
    • apoptosis inducing factor, mitochondria associated 1
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1999-05-28
  • Entrez gene record
  • Pubmed identfication
  • Havana BLAST/BLAT
  • Locus Specific Databases
MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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