LSD1 Substrate

Storage temperature

store cold
Expiry date

1 y
Category

research antibodies, ELISAs, recombinant proteins, vectors and reagents for laboratory use
Gene

Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the Flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.

Identity

HGNC:29079
Gene

KDM1A
Long gene name

lysine demethylase 1A
Synonyms gene
- AOF2
- KDM1
Synonyms gene name
- amine oxidase (flavin containing) domain 2
- lysine (K)-specific demethylase 1
Synonyms
- KIAA0601
- BHC110
- LSD1
Synonyms name
- Lysine-specific histone demethylase 1A
GenBank acession
- AL031428
Locus

1p36.12
Discovery year

2004-02-26
Entrez gene record

23028
Pubmed identfication
- 9628581
- 12493763
RefSeq identity
- NM_015013
Classification
- MicroRNA protein coding host genes
- Lysine demethylases
VEGA ID

OTTHUMG00000003220