Salmonella antibody LPS core
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Catalog number
10-S05F
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Price
Please ask
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Size
200 µg
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Category
Primary Antibody
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Antibody Subtype
Monoclonal Antibodies
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Area of research
Infectious Disease
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Type of Immunogen
Salmonella antibody (LPS core) was raised in mouse using LPS core of Salmonella ..
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Raised in
Mouse
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Specificity
Salmonellae
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Cross Reactivity
This antibopdy recognizes the LPS core protein and reacts with all Salmonella O-serogroups tested: A, B, C1 C2, D, E1, E3, E4, F, G1 and G2
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Isotypes
IgG2a
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Clone
M9011221
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Grade Purity
Grater than 90% pure
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Concentration
Batch dependent
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Form Buffer
10 mM PBS, pH 7.2, with 0.1% NaN3.
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Storage
Aliquot and store at -20 deg C. Avoid repeated freeze/thaw cycles
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Shipping conditions
Blue Ice
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Tested for
ELISA; IF
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Usage Recommendations
Optimal conditions to be determined by end user
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Assay Information
Matched pair antibody available for Salmonella antibody (LPS core): 10-S05I
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Properties
If you buy Antibodies supplied by fitzgerald they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Gene
Bacterial pathogen lipopolysaccharides (LPS) are the major outer surface membrane components present in almost all Gram-negative bacteria and act as extremely strong stimulators of innate or natural immunity in diverse eukaryotic species ranging from insects to humans. LPS consist of a poly- or oligosaccharide region that is anchored in the outer bacterial membrane by a specific carbohydrate lipid moiety termed lipid A. The lipid A component is the primary immunostimulatory center of LPS. With respect to immunoactivation in mammalian systems, the classical group of strongly agonistic (highly endotoxin) forms of LPS has been shown to be comprised of a rather similar set of lipid A types. In addition, several natural or derivative lipid A structures have been identified that display comparatively low or even no immunostimulation for a given mammalian species. Some members of the latter more heterogeneous group are capable of antagonizing the effects of strongly stimulatory LPS/lipid A forms. Agonistic forms of LPS or lipid A trigger numerous physiological immunostimulatory effects in mammalian organisms, but--in higher doses--can also lead to pathological reactions such as the induction of septic shock. Cells of the myeloid lineage have been shown to be the primary cellular sensors for LPS in the mammalian immune system. During the past decade, enormous progress has been obtained in the elucidation of the central LPS/lipid A recognition and signaling system in mammalian phagocytes. According to the current model, the specific cellular recognition of agonistic LPS/lipid A is initialized by the combined extracellular actions of LPS binding protein (LBP), the membrane-bound or soluble forms of CD14 and the newly identified Toll-like receptor 4 (TLR4)*MD-2 complex, leading to the rapid activation of an intracellular signaling network that is highly homologous to the signaling systems of IL-1 and IL-18. The elucidation of structure-activity correlations in LPS and lipid A has not only contributed to a molecular understanding of both immunostimulatory and toxic septic processes, but has also re-animated the development of new pharmacological and immuno-stimulatory strategies for the prevention and therapy of infectious and malignant diseases.
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French translation
anticorps
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Gene target
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Gene symbol
IRF6
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Short name
Salmonella antibody LPS core
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Technique
Antibody, antibodies against human proteins, antibodies for
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Species
Salmonella, Salmonellas
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Alternative name
Mouse monoclonal Salmonella antibody (LPS core)
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Alternative technique
antibodies
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Disease
Salmonella typhimurium, enteriditis and Salmonella paratyphi antibodies or media detect this rod-shaped (bacillus) gram-negative bacteria of the Enterobacteriaceae family. The two species of Salmonella are Salmonella enterica and Salmonella bongori. Salmonella enterica is the type species and is further divided into six subspecies that include over 2500 serovars.
S. enterica subspecies are found worldwide in all warm-blooded animals, and in the environment. S. bongori is restricted to cold-blooded animals particularly reptiles. Strains of Salmonella cause illnesses such as typhoid fever, paratyphoid fever, and food poisoning (salmonellosis).
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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