anti- Notch1 antibody

• Catalog number
  FNab05798
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
• Immunogen
  Notch gene homolog 1 (Drosophila)
• Synonyms
  TAN1
• Calculated MW
  120 kDa
• Uniprot ID
  P46531
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:100 - 1:200
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Notch1  
• Gene symbol
  NOTCH1, NALT1, CRPPA
• Short name
  anti- Notch1 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- notch 1 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  notch 1, AOS5 and AOVD1 and hN1 and TAN1, NOTCH1 and IDBG-92445 and ENSG00000148400 and 4851, sequence-specific DNA binding, nuclei, Notch1 and IDBG-149571 and ENSMUSG00000026923 and 18128, NOTCH1 and IDBG-640538 and ENSBTAG00000022799 and 767866

Gene info

• Identity
  HGNC:7881
• Gene
  NOTCH1
• Long gene name
  notch receptor 1
• Synonyms gene
  • TAN1
• Synonyms gene name
  • Notch (Drosophila) homolog 1 (translocation-associated)
  • Notch homolog 1, translocation-associated (Drosophila)
  • notch 1
• GenBank acession
  • AF308602
• Locus
  9q34.3
• Discovery year
  1992-02-13
• Entrez gene record
  4851
• Pubmed identfication
  • 1831692
• RefSeq identity
  • NM_017617
• Classification
  • Notch receptors
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000020935
• Locus Specific Databases
  • LRG_1122

Gene info

• Identity
  HGNC:51192
• Gene
  NALT1
• Long gene name
  NOTCH1 associated lncRNA in T cell acute lymphoblastic leukemia 1
• Synonyms gene
  • MIR4674HG
  • LINC01573
• Synonyms gene name
  • MIR4674 host gene (non-protein coding)
  • long intergenic non-protein coding RNA 1573
• Synonyms
  • TCONS_l2_00029132
• Locus
  9q34.3
• Discovery year
  2014-08-01
• Entrez gene record
  101928483
• Pubmed identfication
  • 26330272
• RefSeq identity
  • NR_121577
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000020933

Gene info

• Identity
  HGNC:37276
• Gene
  CRPPA
• Long gene name
  CDP-L-ribitol pyrophosphorylase A
• Synonyms gene
  • ISPD
• Synonyms gene name
  • isoprenoid synthase domain containing
• Synonyms
  • hCG_1745121
  • IspD
  • Nip
• Synonyms name
  • notch1-induced protein
  • 4-diphosphocytidyl-2C-methyl-D-erythritol synthase homolog (Arabidopsis)
  • D-ribitol-5-phosphate cytidylyltransferase
• GenBank acession
  • AK124805
• Locus
  7p21.2
• Discovery year
  2009-10-02
• Entrez gene record
  729920
• Pubmed identfication
  • 11181995
  • 28810660
• RefSeq identity
  • NM_001101426
• VEGA ID
  OTTHUMG00000152447

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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