anti- ADAM17 antibody
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Catalog numberFNab00138
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PricePlease ask
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Size2X100μg
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Formliquid
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PurificationImmunogen affinity purified
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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BackgroundThis gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.
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ImmunogenADAM metallopeptidase domain 17
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SynonymsADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme
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Calculated MW115 kDa
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Uniprot IDP78536
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SpecificityHuman, Mouse, Rat
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Tested ApplicationELISA, WB, IHC
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Recommended dilutionWB: 1:500 - 1:2000; IHC: 1:100 - 1:200
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Image1Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using FNab00138( ADAM17 Antibody) at dilution of 1:100
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Image4U-937 cells were subjected to SDS PAGE followed by western blot with FNab00138( ADAM17 Antibody) at dilution of 1:1000
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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PropertiesIf you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolADAM17
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Short nameanti- ADAM17 antibody
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TechniqueAntibody, anti, antibody to, antibodies against human proteins, antibodies for
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HostRabbit
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IsotypeIgG
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Alternative nameantibody to- ADAM metallopeptidase domain 17 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetADAM metallopeptidase domain 17, ADAM18 and CD156B and CSVP and NISBD and TACE, ADAM17 and IDBG-27788 and ENSG00000151694 and 6868, PDZ domain binding, Cell surfaces, Adam17 and IDBG-130508 and ENSMUSG00000052593 and 11491, ADAM17 and IDBG-638333 and ENSBTAG00000001141 and 517541
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Gene info
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Identity
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Gene
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Long gene nameADAM metallopeptidase domain 17
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor, alpha, converting enzyme
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-04-10
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Entrez gene record
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Pubmed identfication
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Classification
- ADAM metallopeptidase domain containing
- CD molecules
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data