STIM1 / GOK monoclonal antibody
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Catalog number11-497-C100
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PricePlease ask
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Size100ug
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Long nameMouse Monoclonal Antibody against Human STIM1 / GOK, Clone: CDN3H4
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AntigenSTIM1
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Species reactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat
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Negative species reactivityat the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
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ClonalityMonoclonal Antibody (Mab)
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CloneCDN3H4
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ApplicationsIP, WB, IHC(P), ICC
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ImmunogenSynthetized peptide (C-terminal cytoplasmic part of STIM1).
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Format conjugationpurified; unconjugated
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SpecificityThe antibody CDN3H4 reacts with human and rodent STIM1, a 84 kDa essential and conserved regulator of store-operated Ca2+ channel function.
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Research areaCalcium Signaling (Rodent), Calcium Signaling (Human)
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Concentration1 mg/ml
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Storage bufferPhosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
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Shipping and storageMouse Monoclonal Antibody against Human STIM1 / GOK, Clone: CDN3H4 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
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BackgroundSTIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
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Purity> 95% (by SDS-PAGE)
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Purification methodPurified by protein-A affinity chromatography
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References*Hájková Z, Bugajev V, Dráberová E, Vinopal S, Dráberová L, Janáček J, Dráber P, Dráber P: STIM1-directed reorganization of microtubules in activated mast cells. J Immunol. 2011 Jan 15;186(2):913-23.
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PropertiesIf you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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French translationanticorps
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Gene target
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Gene symbolSTIM1, STIM1-AS1
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Short nameAnti-STIM1 / GOK Mab
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TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
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HostMouse (Mus musculus)
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IsotypeIgG1
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Alternative nameMouse Monoclonal to STIM1 / GOK
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namestromal interaction molecule 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-02-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Sterile alpha motif domain containing
- MicroRNA protein coding host genes
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameSTIM1 antisense RNA 1
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Locus
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Discovery year2020-03-27
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Entrez gene record
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Classification
- Antisense RNAs
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data