EGFR (Phospho-Tyr1173) monoclonal antibody

• Catalog number
  11-575-C100
• Price
  Please ask
• Size
  100ug

• Long name
  Mouse Monoclonal Antibody against Human EGFR (Phospho-Tyr1173), Clone: EM-13
• Antigen
  EGFR (Phospho-Tyr1173)
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  EM-13
• Applications
  FC, IP, WB
• Immunogen
  Synthetic phospho-peptide covering sequence around tyrosine 1173 of human EGFR.
• Format conjugation
  purified; unconjugated
• Specificity
  The antibody EM-13 reacts with human EGFR (ErbB1 / HER1) phosphorylated on tyrosine 1173.
• Research area
  Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human)
• Concentration
  1 mg/ml
• Storage buffer
  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Shipping and storage
  Mouse Monoclonal Antibody against Human EGFR (Phospho-Tyr1173), Clone: EM-13 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by protein-A affinity chromatography
• Datasheet
• References
  Contact us for the most recent list of references
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  EGFR   Phospho-Tyr1173   monoclonal  
• Gene symbol
  EGFR-AS1, EGILA, EGFR, RHBDF1
• Short name
  Anti-EGFR (Phospho-Tyr1173) Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to EGFR (Phospho-Tyr1173)
• Alternative technique
  antibodies
• Alternative to gene target
  epidermal growth factor receptor, ERBB and ERBB1 and HER1 and mENA and PIG61, EGFR and IDBG-16933 and ENSG00000146648 and 1956, transferase activity, nuclei, Egfr and IDBG-151194 and ENSMUSG00000020122 and 13649, EGFR and IDBG-644035 and ENSBTAG00000011628 and 407217

Gene info

• Identity
  HGNC:40207
• Gene
  EGFR-AS1
• Long gene name
  EGFR antisense RNA 1
• Locus
  7p11.2
• Discovery year
  2012-11-06
• Entrez gene record
  100507500
• Pubmed identfication
  • 26271667
  • 28920960
• RefSeq identity
  • NR_047551
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000156126

Gene info

• Identity
  HGNC:54482
• Gene
  EGILA
• Long gene name
  EGFR interacting lncRNA
• Synonyms
  • Lnc-EGFR
• Locus
  14q11.2
• Discovery year
  2019-09-27
• Pubmed identfication
  • 28541302
• Classification
  • Long non-coding RNAs with non-systematic symbols

Gene info

• Identity
  HGNC:3236
• Gene
  EGFR
• Long gene name
  epidermal growth factor receptor
• Synonyms gene
  • ERBB
• Synonyms gene name
  • epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
• Synonyms
  • ERBB1
  • ERRP
• Synonyms name
  • erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian)
  • erb-b2 receptor tyrosine kinase 1
• Locus
  7p11.2
• Discovery year
  1986-01-01
• Entrez gene record
  1956
• Pubmed identfication
  • 1505215
• RefSeq identity
  • NM_005228
• Classification
  • Erb-b2 receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000023661
• Locus Specific Databases
  • LRG_304

Gene info

• Identity
  HGNC:20561
• Gene
  RHBDF1
• Long gene name
  rhomboid 5 homolog 1
• Synonyms gene
  • C16orf8
• Synonyms gene name
  • chromosome 16 open reading frame 8
  • rhomboid family 1 (Drosophila)
  • rhomboid 5 homolog 1 (Drosophila)
• Synonyms
  • EGFR-RS
  • FLJ2235
  • Dist1
  • iRhom1
• GenBank acession
  • BC014425
• Locus
  16p13.3
• Discovery year
  2003-04-07
• Entrez gene record
  64285
• Pubmed identfication
  • 8318735
  • 15965977
• RefSeq identity
  • NM_022450
• Classification
  • Rhomboid family
• VEGA ID
  OTTHUMG00000060719

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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