DR3 / TRAMP monoclonal antibody

• Catalog number
  11-757-C100
• Price
  Please ask
• Size
  100ug

• Long name
  Mouse Monoclonal Antibody against Human DR3 / TRAMP, Clone: JD3
• Antigen
  DR3 / TRAMP
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  JD3
• Applications
  FC
• Immunogen
  human DR3-Ig fusion protein
• Format conjugation
  purified; unconjugated
• Specificity
  The mouse monoclonal antibody JD3 recognizes DR3 (APO-3, TNFRSF12), a transmembrane protein of TNFR superfamily expressed mainly in lymphocyte-enriched tissues.
• Research area
  CD and Related Antigens (Human), Apoptosis (Human)
• Concentration
  1 mg/ml
• Storage buffer
  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Shipping and storage
  Mouse Monoclonal Antibody against Human DR3 / TRAMP, Clone: JD3 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  DR3, also known as APO-3, TRAMP or TNFRSF12, is a death domain-containing receptor of TNFR family, which is expressed preferentially in peripheral blood leukocytes and in the lymphocyte-enriched tissues. Its expression has been shown to be especially up-regulated in activated T cells. DR3 participates e.g. in the removal of self-reactive T cells in the thymus. The ligand for DR3 is TL1A (TNF-like ligand 1A), which is expressed in a variety of cell types (induced by inflammatory stimuli), and can also be released as a soluble factor. The TL1A/DR3 axis has been shown to costimulate T cells to produce a wide variety of cytokines and leads to T cell differentiation towards Th1 and Th17 types.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by protein-A affinity chromatography
• Datasheet
• References
  *Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA: Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J. 2011 Jan;25(1):409-19., *Cavallini C, Lovato O, Bertolaso A, Pacelli L, Zoratti E, Zanolin E, Krampera M, Zamò A, Tecchio C, Cassatella MA, Pizzolo G, Scupoli MT: The TNF-family cytokine TL1A inhibits proliferation of human activated B cells. PLoS One. 2013;8(4):e60136., *Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H: Multiple pathways of TWEAK-induced cell death. J Immunol. 2002 Jan 15;168(2):734-43., *Yi B, Zhang M, Schwartz-Albiez R, Cao Y: Mechanisms of the apoptosis induced by CD176 antibody in human leukemic cells. Int J Oncol. 2011 Jun;38(6):1565-73.
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  DR3   TRAMP   monoclonal  
• Gene symbol
  TNFRSF25, TRAM1, ZBED1
• Short name
  Anti-DR3 / TRAMP Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to DR3 / TRAMP
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11910
• Gene
  TNFRSF25
• Long gene name
  TNF receptor superfamily member 25
• Synonyms gene
  • TNFRSF12
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
  • tumor necrosis factor receptor superfamily, member 25
• Synonyms
  • DR3
  • TRAMP
  • WSL-1
  • LARD
  • WSL-LR
  • DDR3
  • TR3
  • APO-3
• GenBank acession
  • U72763
• Locus
  1p36.31
• Discovery year
  1998-12-04
• Entrez gene record
  8718
• Pubmed identfication
  • 9052839
  • 8934525
• RefSeq identity
  • NM_148965
• Classification
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000000831

Gene info

• Identity
  HGNC:20568
• Gene
  TRAM1
• Long gene name
  translocation associated membrane protein 1
• Synonyms
  • TRAM
  • TRAMP
• GenBank acession
  • X63679
• Locus
  8q13.3
• Discovery year
  2003-04-03
• Entrez gene record
  23471
• Pubmed identfication
  • 1315422
• RefSeq identity
  • NM_014294
• Classification
  • TLC domain containing
• VEGA ID
  OTTHUMG00000164428

Gene info

• Identity
  HGNC:447
• Gene
  ZBED1
• Long gene name
  zinc finger BED-type containing 1
• Synonyms gene
  • ALTE
• Synonyms gene name
  • Ac-like transposable element
• Synonyms
  • TRAMP
  • KIAA0785
  • DREF
  • hDREF
• GenBank acession
  • AB018328
• Locus
  Xp22.33 and Yp11
• Discovery year
  2000-05-11
• Entrez gene record
  9189
• Pubmed identfication
  • 9872452
  • 9887332
  • 23533661
• RefSeq identity
  • NM_004729
• Classification
  • Zinc fingers BED-type
  • Pseudoautosomal region 1
• VEGA ID
  OTTHUMG00000021069
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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