Daxx / DAP6 monoclonal antibody
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Catalog number11-351-C025
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PricePlease ask
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Size25ug
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Long nameMouse Monoclonal Antibody against Human Daxx / DAP6, Clone: DAXX-01
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AntigenDaxx
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Species reactivityHuman (Homo sapiens)
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Negative species reactivityat the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
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ClonalityMonoclonal Antibody (Mab)
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CloneDAXX-01
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ApplicationsWB, ICC
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ImmunogenRecombinant C-terminal part (aa 558-740) of human Daxx.
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Format conjugationpurified; unconjugated
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SpecificityThe antibody DAXX-01 reacts with Daxx, a death domain containing protein mainly expressed in fetal and adult human and mouse tissue.
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Research areaTranscription Regulation & Nuclear Proteins (Human), Apoptosis (Human), Transcription Regulation & Nuclear Proteins, Apoptosis
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Concentration1 mg/ml
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Storage bufferPhosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
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Shipping and storageMouse Monoclonal Antibody against Human Daxx / DAP6, Clone: DAXX-01 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
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BackgroundDaxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1)._x000D_
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Purity> 95% (by SDS-PAGE)
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Purification methodPurified by protein-A affinity chromatography
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References*Leal-Sanchez J, Couzinet A, Rossin A, Abdel-Sater F, Chakrabandhu K, Luci C, Anjuere F, Stebe E, Hancock D, Hueber AO.: Requirement for Daxx in mature T-cell proliferation and activation. Cell Death Differ. 2007 Apr;14(4):795-806.
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PropertiesIf you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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French translationanticorps
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Gene target
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Gene symbolDAXX
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Short nameAnti-Daxx / DAP6 Mab
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TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
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HostMouse (Mus musculus)
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IsotypeIgG1
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Alternative nameMouse Monoclonal to Daxx / DAP6
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Alternative techniqueantibodies
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Alternative to gene targetdeath-domain associated protein, BING2 and DAP6 and EAP1, DAXX and IDBG-82726 and ENSG00000204209 and 102723452,1616, androgen receptor binding, nuclei, Daxx and IDBG-168138 and ENSMUSG00000002307 and 13163, DAXX and IDBG-629026 and ENSBTAG00000016830 and 504336
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Gene info
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Identity
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Gene
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Long gene namedeath domain associated protein
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Synonyms gene name
- death-associated protein 6
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-03-25
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Entrez gene record
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Pubmed identfication
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data