CD84 monoclonal antibody
-
Catalog number11-661-C100
-
PricePlease ask
-
Size100ug
-
-
Long nameMouse Monoclonal Antibody against Human CD84, Clone: CD84.1.21
-
AntigenCD84
-
Species reactivityHuman (Homo sapiens)
-
Negative species reactivityat the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
-
ClonalityMonoclonal Antibody (Mab)
-
CloneCD84.1.21
-
ApplicationsFC, IP, FUNC
-
ImmunogenCD84-transfected 300.19 cell line
-
Format conjugationpurified; unconjugated
-
SpecificityThe mouse monoclonal antibody CD84.1.21 recognizes CD84, a single chain cell surface glycoprotein of 64-82 kDa, predominantly expressed B cells, monocytes, platelets and some T cells.
-
Research areaCD and Related Antigens (Human)
-
Concentration1 mg/ml
-
Storage bufferPhosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
-
Shipping and storageMouse Monoclonal Antibody against Human CD84, Clone: CD84.1.21 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
-
BackgroundCD84 is a highly glycosylated homophilic receptor of SLAM family. It is expressed on platelets and various types of leukocytes, especially following their activation. Ligation of CD84 leads to its phosphorylation on tyrosine residues within the cytoplasmic tail. These docking sites are recognized by downstream signaling molecules, such as phosphatase SHP-2 and adaptor protein SAP/SH2D1A. The function of CD84 has not been fully elucidated yet. Although predominantly activating receptor, its modulating activity was also demonstrated.
-
Purity> 95% (by SDS-PAGE)
-
Purification methodPurified by protein-A affinity chromatography
-
References*Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P: CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. J Immunol. 2005 Jun 1;174(11):7033-42., *Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C: Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. J Biol Chem. 2001 Sep 28;276(39):36809-16., *Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C: Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J. 2001 Nov 1;20(21):5840-52., *Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P: CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma_x000D_ secretion: adhesion is mediated by Ig-like domain 1. J Immunol. 2001 Oct 1;167(7):3668-76., *Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C: Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP. Blood. 2001 Jun 15;97(12):3867-74.
-
PropertiesIf you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
-
French translationanticorps
-
Gene target
-
Gene symbolCD84, SLAMF9
-
Short nameAnti-CD84 Mab
-
TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
-
HostMouse (Mus musculus)
-
IsotypeIgG2a
-
Alternative nameMouse Monoclonal to CD84
-
Alternative techniqueantibodies
-
Alternative to gene targetCD84 molecule, hCD84 and LY9B and mCD84 and SLAMF5, CD84 and IDBG-104060 and ENSG00000066294 and 8832, protein binding, Plasma membranes, Cd84 and IDBG-204869 and ENSMUSG00000038147 and 12523, CD84 and IDBG-630532 and ENSBTAG00000019033 and
-
Gene info
-
Identity
-
Gene
-
Long gene nameCD84 molecule
-
Synonyms gene name
- CD84 antigen (leukocyte antigen)
- CD84 molecule
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1999-01-18
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Ig-like cell adhesion molecule family
- Immunoglobulin like domain containing
- CD molecules
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameSLAM family member 9
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-10-29
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- V-set domain containing
-
VEGA ID