CD64 / FcgammaRI monoclonal antibody

• Catalog number
  T4-644-T025
• Price
  Please ask
• Size
  25 assays

• Long name
  Mouse Monoclonal Antibody against Human CD64 / FcgammaRI, Clone: 10.1
• Antigen
  CD64
• Species reactivity
  Human (Homo sapiens), Non-Human (Homo sapiens) Primates
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  10.1
• Applications
  FC, IP, WB, IHC(P), IHC(F), ICC, FUNC
• Immunogen
  Rheumatoid synovial fluid cells and fibronectin purified human monocytes
• Format conjugation
  APC-Cy 7
• Specificity
  The mouse monoclonal antibody 10.1 recognizes alpha subunit of CD64/FcgammaRI, a 72 kDa single chain type I glycoprotein, that is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes._x000D_ HLDA III; WS Code M-250
• Research area
  CD and Related Antigens (Human)
• Storage buffer
  The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD64 / FcgammaRI, Clone: 10.1 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD64 (FcgammaRI) is a cell surface receptor for Fc region of IgG. It is composed of specific ligand binding alpha subunit and promiscuous gamma subunit, which is indispensable for tyrosine-based signaling. However, even the alpha subunit can transduce signals leading to cellular effector functions. The isoform FcgammaRIa1 binds human IgG with high affinity, has limited myeloid cell distribution, and a relatively large intracellular domain. Products of related genes include FcgammaRIb and FcgammaRIc isoforms, but these specify low affinity IgG receptors if functionally expressed at all. Besides a role in antigen clearance, FcgammaRI (a1) can potently enhance MHC class I and II antigen presentation in vitro and in vivo.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by affinity chromatography
• Datasheet
• References
  Contact us for the most recent list of references
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD64   FcgammaRI   monoclonal  
• Gene symbol
  FCGR1A
• Short name
  Anti-CD64 / FcgammaRI Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to CD64 / FcgammaRI
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3613
• Gene
  FCGR1A
• Long gene name
  Fc gamma receptor Ia
• Synonyms gene name
  • Fc fragment of IgG, high affinity Ia, receptor for (CD64)
  • Fc fragment of IgG, high affinity Ia, receptor (CD64)
  • Fc fragment of IgG receptor Ia
• Synonyms
  • CD64
  • CD64A
  • FcgammaRI
  • FcgammaRIa
  • FCG1
  • FCGR1
• Synonyms name
  • Fc gamma RI
• GenBank acession
  • BC032634
• Locus
  1q21.2
• Discovery year
  1992-12-03
• Entrez gene record
  2209
• Pubmed identfication
  • 8697799
  • 9763663
• RefSeq identity
  • NM_000566
• Classification
  • CD molecules
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000012089
• Locus Specific Databases
  • FCGR1Abase: Mutation registry for CD64 deficiency
  • LRG_59

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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