CD59 / Protectin monoclonal antibody

• Catalog number
  11-233-C025
• Price
  Please ask
• Size
  25ug

• Long name
  Mouse Monoclonal Antibody against Human CD59 / Protectin, Clone: MEM-43
• Antigen
  CD59
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  MEM-43
• Applications
  FC, IP, IHC(P)
• Immunogen
  Thymocytes and T lymphocytes
• Format conjugation
  purified; unconjugated
• Specificity
  The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues._x000D_ HLDA IV; WS Code NL 705_x000D_ HLDA V; WS Code AS S013_x000D_ HLDA V; WS Code BP BP345_x000D_ HLDA V; WS Code T T-103_x000D_
• Research area
  CD and Related Antigens (Human)
• Concentration
  1 mg/ml
• Storage buffer
  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD59 / Protectin, Clone: MEM-43 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by protein-A affinity chromatography
• Datasheet
• References
  , *Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995)._x000D_ , *Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989).
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD59   Protectin   monoclonal  
• Gene symbol
  CD59
• Short name
  Anti-CD59 / Protectin Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG2a
• Alternative name
  Mouse Monoclonal to CD59 / Protectin
• Alternative technique
  antibodies
• Alternative to gene target
  CD59 molecule, complement regulatory protein, 16.3A5 and 1F5 and EJ16 and EJ30 and EL32 and G344 and HRF-20 and HRF20 and MAC-IP and MACIF and MEM43 and MIC11 and MIN1 and MIN2 and MIN3 and MIRL and MSK21 and p18-20, CD59 and IDBG-38813 and ENSG00000085063 and 966, protein binding, Extracellular, CD59 and IDBG-636427 and ENSBTAG00000002302 and 505574

Gene info

• Identity
  HGNC:1689
• Gene
  CD59
• Long gene name
  CD59 molecule (CD59 blood group)
• Synonyms gene
  • MIC11
  • MIN1
  • MSK21
  • MIN2
  • MIN3
• Synonyms gene name
  • CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
  • CD59 antigen, complement regulatory protein
  • CD59 molecule, complement regulatory protein
  • CD59 molecule
• Synonyms
  • 16.3A5
  • EJ16
  • EJ30
  • EL32
  • G344
  • p18-20
• Locus
  11p13
• Discovery year
  1989-06-30
• Entrez gene record
  966
• Pubmed identfication
  • 7691713
  • 27187193
• RefSeq identity
  • NM_203329
• Classification
  • Blood group antigens
  • Complement system regulators and receptors
  • CD molecules
  • LY6/PLAUR domain containing
• VEGA ID
  OTTHUMG00000166270
• Locus Specific Databases
  • CD59base: Mutation registry for CD59 deficiency
  • LRG_41

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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