CD27 monoclonal antibody

• Catalog number
  PO-308-T025
• Price
  Please ask
• Size
  25 assays

• Long name
  Mouse Monoclonal Antibody against Human CD27, Clone: LT27
• Antigen
  CD27
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  LT27
• Applications
  FC
• Immunogen
  Human peripheral blood lymphocytes
• Format conjugation
  Pacific Orange
• Specificity
  The antibody LT27 reacts with CD27 (T14), a 50-55 kDa type I transmembrane glycoprotein (member of the TNF-receptor superfamily) expressed on medullary thymocytes, peripheral T lymphocytes, some B lymphocytes and NK cells.HLDA V; WS Code T T-CD27.01
• Research area
  CD and Related Antigens (Human)
• Storage buffer
  The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD27, Clone: LT27 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD27 is a transmembrane 55 kDa protein of the nerve growth factor-receptor family, expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. This sCD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by affinity chromatography
• Datasheet
• References
  *Kanderova V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, Hrusak O, Lund-Johansen F, Kalina T: High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016 Apr;15(4):1246-61., *Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD27   monoclonal  
• Gene symbol
  CD27-AS1, CD27
• Short name
  Anti-CD27 Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG2a
• Alternative name
  Mouse Monoclonal to CD27
• Alternative technique
  antibodies
• Alternative to gene target
  CD27 molecule, S152 and S152. LPFS2 and T14 and TNFRSF7 and Tp55, CD27 and IDBG-14014 and ENSG00000139193 and 939, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, Extracellular, Cd27 and IDBG-189750 and ENSMUSG00000030336 and 21940, CD27 and IDBG-640494 and ENSBTAG00000014725 and 512514

Gene info

• Identity
  HGNC:43896
• Gene
  CD27-AS1
• Long gene name
  CD27 antisense RNA 1
• Synonyms gene name
  • CD27 antisense RNA 1 (non-protein coding)
• GenBank acession
  • AK056500
• Locus
  12p13.31
• Discovery year
  2012-04-27
• Entrez gene record
  678655
• RefSeq identity
  • NR_015382
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000168315

Gene info

• Identity
  HGNC:11922
• Gene
  CD27
• Long gene name
  CD27 molecule
• Synonyms gene
  • TNFRSF7
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 7
• Synonyms
  • S152
  • Tp55
• GenBank acession
  • M63928
• Locus
  12p13.31
• Discovery year
  1992-06-10
• Entrez gene record
  939
• Pubmed identfication
  • 2442250
  • 8530100
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000168316
• Locus Specific Databases
  • LRG_357

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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