CD262 / TRAIL-R2 monoclonal antibody

• Catalog number
  1P-461-C100
• Price
  Please ask
• Size
  100ug

• Long name
  Mouse Monoclonal Antibody against Human CD262 / TRAIL-R2, Clone: DR5-01-1
• Antigen
  CD262 / TRAIL-R2
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  DR5-01-1
• Applications
  FC
• Immunogen
  Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.
• Format conjugation
  PE
• Specificity
  The antibody DR5-01-1 recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). _x000D_ _x000D_
• Research area
  Apoptosis (Human), CD and Related Antigens (Human), Apoptosis
• Concentration
  0.1 mg/ml
• Storage buffer
  The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD262 / TRAIL-R2, Clone: DR5-01-1 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  TRAIL-R2 (CD262, DR5) is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by affinity chromatography
• Datasheet
• References
  Contact us for the most recent list of references
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD262   TRAIL-R2   monoclonal  
• Gene symbol
  TNFRSF10B, PCAT7, CD82, TNFSF10, CLDN3
• Short name
  Anti-CD262 / TRAIL-R2 Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to CD262 / TRAIL-R2
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:11905
• Gene
  TNFRSF10B
• Long gene name
  TNF receptor superfamily member 10b
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 10b
• Synonyms
  • DR5
  • KILLER
  • TRICK2A
  • TRAIL-R2
  • TRICKB
  • CD262
  • TRAILR2
• GenBank acession
  • AF012628
• Locus
  8p21.3
• Discovery year
  1998-12-04
• Entrez gene record
  8795
• Pubmed identfication
  • 9285725
  • 9311998
• RefSeq identity
  • NM_147187
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000097826

Gene info

• Identity
  HGNC:48824
• Gene
  PCAT7
• Long gene name
  prostate cancer associated transcript 7
• Synonyms gene name
  • prostate cancer associated transcript 7 (non-protein coding)
• Synonyms
  • PCAN-R2
• Synonyms name
  • prostate cancer-associated noncoding RNA 2
• Locus
  9q22.32
• Discovery year
  2013-06-14
• Entrez gene record
  101928099
• Pubmed identfication
  • 23728290
• RefSeq identity
  • NR_121566
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000020270

Gene info

• Identity
  HGNC:6210
• Gene
  CD82
• Long gene name
  CD82 molecule
• Synonyms gene
  • ST6
  • KAI1
• Synonyms gene name
  • kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
  • CD82 antigen
• Synonyms
  • R2
  • IA4
  • TSPAN27
• Synonyms name
  • suppression of tumorigenicity 6
  • R2 leukocyte antigen
• GenBank acession
  • U20770
• Locus
  11p11.2
• Discovery year
  1994-01-10
• Entrez gene record
  3732
• RefSeq identity
  • NM_002231
• Classification
  • Tetraspanins
  • CD molecules
• VEGA ID
  OTTHUMG00000166472

Gene info

• Identity
  HGNC:11925
• Gene
  TNFSF10
• Long gene name
  TNF superfamily member 10
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 10
• Synonyms
  • TRAIL
  • Apo-2L
  • TL2
  • CD253
• GenBank acession
  • U37518
• Locus
  3q26
• Discovery year
  1998-12-04
• Pubmed identfication
  • 8777713
  • 8663110
• Classification
  • CD molecules
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000156917

Gene info

• Identity
  HGNC:2045
• Gene
  CLDN3
• Long gene name
  claudin 3
• Synonyms gene
  • C7orf1
  • CPETR2
• Synonyms
  • RVP1
  • CPE-R2
  • HRVP1
• Synonyms name
  • Clostridium perfringens enterotoxin receptor 2
  • ventral prostate.1-like protein
  • claudin-3
  • CPE-receptor 2
• GenBank acession
  • AF007189
• Locus
  7q11.23
• Discovery year
  1998-07-23
• Entrez gene record
  1365
• Pubmed identfication
  • 9441748
  • 9892664
• RefSeq identity
  • NM_001306
• Classification
  • Claudins
• VEGA ID
  OTTHUMG00000023424

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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