CD19 monoclonal antibody
-
Catalog numberT8-663-T100
-
PricePlease ask
-
Size100 assays
-
-
Long nameMouse Monoclonal Antibody against Human CD19, Clone: 4G7
-
AntigenCD19
-
Species reactivityHuman (Homo sapiens)
-
Negative species reactivityat the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
-
ClonalityMonoclonal Antibody (Mab)
-
Clone4G7
-
ApplicationsFC, ICC
-
ImmunogenHuman CCL (chronic lymphocytic leukemia) cells
-
Format conjugationPE-Cy 5
-
SpecificityThe mouse monoclonal antibody 4G7 recognizes CD19 (B4), a 95 kDa type I transmembrane glycoprotein of immunoglobulin superfamily, expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells._x000D_ WS Code: 2 B43
-
Research areaCD and Related Antigens (Human)
-
Storage bufferThe reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
-
Shipping and storageMouse Monoclonal Antibody against Human CD19, Clone: 4G7 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
-
BackgroundCD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
-
Purity> 95% (by SDS-PAGE)
-
Purification methodPurified by affinity chromatography
-
ReferencesContact us for the most recent list of references
-
PropertiesIf you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
AboutMonoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
-
French translationanticorps
-
Gene target
-
Gene symbolCD19
-
Short nameAnti-CD19 Mab
-
TechniqueAntibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
-
HostMouse (Mus musculus)
-
IsotypeIgG1
-
Alternative nameMouse Monoclonal to CD19
-
Alternative techniqueantibodies
-
Alternative to gene targetCD19 molecule, B4 and CVID3, CD19 and IDBG-23791 and ENSG00000177455 and 930, protein binding, Cell surfaces, Cd19 and IDBG-209475 and ENSMUSG00000030724 and 12478, CD19 and IDBG-638894 and ENSBTAG00000032122 and
-
Gene info
-
Identity
-
Gene
-
Long gene nameCD19 molecule
-
Synonyms gene name
- CD19 antigen
-
Locus
-
Discovery year1991-06-04
-
Entrez gene record
-
Classification
- CD molecules
- Immunoglobulin like domain containing
- Minor histocompatibility antigens
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data