ARAP1 / centaurin monoclonal antibody

• Catalog number
  11-516-C025
• Price
  Please ask
• Size
  25ug

• Long name
  Mouse Monoclonal Antibody against Human ARAP1 / centaurin, Clone: ARAP1-2
• Antigen
  ARAP1
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  ARAP1-2
• Applications
  IP, WB, ICC
• Immunogen
  His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1
• Format conjugation
  purified; unconjugated
• Specificity
  The antibody ARAP1-2 reacts with C-terminal part of ARAP1, a 160 kDa adaptor protein.
• Research area
  Signaling of Small GTPases (Human), Adaptor Proteins (Human), Apoptosis (Human), Adaptor Proteins, Signaling of Small GTPases, Apoptosis
• Concentration
  1 mg/ml
• Storage buffer
  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
• Shipping and storage
  Mouse Monoclonal Antibody against Human ARAP1 / centaurin, Clone: ARAP1-2 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by protein-A affinity chromatography
• Datasheet
• References
  *Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis. 2008 Mar;13(3):423-36._x000D_ _x000D_
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  ARAP1   centaurin   monoclonal  
• Gene symbol
  ARAP1, ARAP1-AS1, ARAP1-AS2
• Short name
  Anti-ARAP1 / centaurin Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to ARAP1 / centaurin
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16925
• Gene
  ARAP1
• Long gene name
  ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
• Synonyms gene
  • CENTD2
• Synonyms gene name
  • centaurin, delta 2
• GenBank acession
  • AF411983
• Locus
  11q13.4
• Discovery year
  2001-10-29
• Entrez gene record
  116985
• RefSeq identity
  • NM_001040118
• Classification
  • Sterile alpha motif domain containing
  • ArfGAPs
  • Pleckstrin homology domain containing
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000157102

Gene info

• Identity
  HGNC:39993
• Gene
  ARAP1-AS1
• Long gene name
  ARAP1 antisense RNA 1
• Synonyms gene name
  • ARAP1 antisense RNA 1 (non-protein coding)
• Locus
  11q13.4
• Discovery year
  2011-04-20
• Pubmed identfication
  • 31173500
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000167950

Gene info

• Identity
  HGNC:39994
• Gene
  ARAP1-AS2
• Long gene name
  ARAP1 antisense RNA 2
• Synonyms gene name
  • ARAP1 antisense RNA 2 (non-protein coding)
• Locus
  11q13.4
• Discovery year
  2011-04-20
• Entrez gene record
  100506020
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000167951

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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