Transcriptional Repressor Ctcf/Ctcf
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Catalog number
E21-F20
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Price
Please ask
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Size
10ug
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Shipping_Temperature
Ambient
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Product_State
Lyophilized
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Formulation_Description
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
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Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Reconstitution
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Endotoxin
Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
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Background
Transcriptional Repressor CTCF (CTCF) belongs to the CTCF Zinc-Finger Protein family. CTCF contains twelve C2H2-type zinc fingers and interacts with CHD8. CTCF is widely expressed in many tissues, and it is absent in primary spermatocytes. CTCF is involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. CTCF plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. In addition, CTCF is also indispensable in the epigenetic regulation and chromatin remodeling.
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Alternative Names
Transcriptional Repressor CTCF; 11-Zinc Finger Protein; CCCTC-Binding Factor; CTCFL Paralog; CTCF
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Expression system
E.coli
Gene info
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Identity
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Gene
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Long gene name
CCCTC-binding factor
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Synonyms gene name
- CCCTC-binding factor (zinc finger protein)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2000-10-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zinc fingers C2H2-type
- Cilia and flagella associated
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VEGA ID
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