S100 Calcium Binding Protein B/S100B

• Catalog number
  E21-K82
• Price
  Please ask
• Size
  10ug

• Shipping_Temperature
  Ambient
• Product_State
  Lyophilized
• Formulation_Description
  Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
• Storage
  Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Reconstitution
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Background
  S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition, S100-B, which is also present in Mouse melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.
• Alternative Names
  Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; S100b; S100 beta; S100 calcium binding protein B
• Expression system
  E.coli

• Gene target
  S100   Calcium   Binding   Protein   B/S100B  
• Gene symbol
  S100B, S100A1, S100Z, S100A8, S100A9
• Short name
  S100 Calcium Binding Protein B/S100B
• Species
  Mouse
• Alternative name
  S100 Calcium Binding Protein B/S100B

Gene info

• Identity
  HGNC:10500
• Gene
  S100B
• Long gene name
  S100 calcium binding protein B
• Synonyms gene name
  • S100 calcium binding protein, beta (neural)
• Synonyms
  • S100beta
• GenBank acession
  • M59488
• Locus
  21q22.3
• Discovery year
  1988-06-27
• Entrez gene record
  6285
• Pubmed identfication
  • 2394738
  • 1998503
• RefSeq identity
  • NM_006272
• Classification
  • S100 calcium binding proteins
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000090715

Gene info

• Identity
  HGNC:10486
• Gene
  S100A1
• Long gene name
  S100 calcium binding protein A1
• Synonyms gene
  • S100A
• Synonyms gene name
  • S100 calcium-binding protein A1
• Synonyms
  • S100-alpha
• GenBank acession
  • BC014392
• Locus
  1q21.3
• Discovery year
  1991-07-10
• Entrez gene record
  6271
• Pubmed identfication
  • 1998503
• RefSeq identity
  • NM_006271
• Classification
  • S100 calcium binding proteins
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000037041

Gene info

• Identity
  HGNC:30367
• Gene
  S100Z
• Long gene name
  S100 calcium binding protein Z
• Synonyms gene name
  • S100 calcium binding protein, zeta
• Synonyms
  • Gm625
  • S100-zeta
• GenBank acession
  • AF437876
• Locus
  5q13.3
• Discovery year
  2004-09-22
• Entrez gene record
  170591
• Pubmed identfication
  • 11747429
• RefSeq identity
  • NM_130772
• Classification
  • S100 calcium binding proteins
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000162441

Gene info

• Identity
  HGNC:10498
• Gene
  S100A8
• Long gene name
  S100 calcium binding protein A8
• Synonyms gene
  • CAGA
  • CFAG
• Synonyms gene name
  • calgranulin A
  • cystic fibrosis antigen
• Synonyms
  • P8
  • MRP8
  • MRP-8
  • 60B8AG
  • CGLA
  • S100-A8
• Synonyms name
  • Migration inhibitory factor-related protein 8
  • Calprotectin L1L subunit
  • Leukocyte L1 complex light chain
• GenBank acession
  • BC005928
• Locus
  1q21.3
• Discovery year
  1989-05-19
• Entrez gene record
  6279
• RefSeq identity
  • NM_002964
• Classification
  • S100 calcium binding proteins
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000013124

Gene info

• Identity
  HGNC:10499
• Gene
  S100A9
• Long gene name
  S100 calcium binding protein A9
• Synonyms gene
  • CAGB
  • CFAG
• Synonyms gene name
  • calgranulin B
  • S100 calcium-binding protein A9 (calgranulin B)
• Synonyms
  • P14
  • MIF
  • NIF
  • LIAG
  • MRP14
  • MAC387
  • 60B8AG
  • CGLB
  • MRP-14
  • S100-A9
• Synonyms name
  • Calprotectin L1H subunit
  • Leukocyte L1 complex heavy chain
  • Migration inhibitory factor-related protein 14
• GenBank acession
  • BC047681
• Locus
  1q21.3
• Discovery year
  1989-05-19
• Entrez gene record
  6280
• RefSeq identity
  • NM_002965
• Classification
  • S100 calcium binding proteins
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000013125

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