Programmed Cell Death 1 Ligand 1/PD-L1/B7-H1/CD274 (C-Fc-Avi)
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Catalog numberE21-CU02
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PricePlease ask
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Size10ug
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Shipping_TemperatureAmbient
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Product_StateLyophilized
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Formulation_DescriptionLyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
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StorageLyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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ReconstitutionAlways centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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PurityGreater than 95% as determined by reducing SDS-PAGE.
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EndotoxinLess than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
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BackgroundCD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
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Alternative NamesProgrammed Cell Death 1 Ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1; B7-H1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
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Expression systemHuman Cells
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DescriptionFor cells, cell lines and tissues in culture till half confluency. FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
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Gene target
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Gene symbolCD274, PDCD1LG2, VSIR, H1-9P, HHLA2, RLN1, H1-8, RNY4P2, LRRC23, ENPP2
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Short nameProgrammed Death 1 Ligand 1/PD-L1/B7-H1/CD274 (C-Fc-Avi)
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TechniqueFC
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SpeciesHuman
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Alternative nameProgrammed cellular Death 1 Ligand 1/PD-L1/B7-H1/CD274 molecule (C-fragment c-Avi)
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Alternative to gene targetCD274 molecule, CD274 and IDBG-47487 and ENSG00000120217 and 29126, protein binding, Cell surfaces, Cd274 and IDBG-157249 and ENSMUSG00000016496 and 60533, PD-L1 and IDBG-631351 and ENSBTAG00000000095 and 533834
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Tissuecell
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Gene info
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Identity
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Gene
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Long gene nameCD274 molecule
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Synonyms gene
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Synonyms gene name
- programmed cell death 1 ligand 1
- CD274 antigen
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-11-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Receptor ligands
- C2-set domain containing
- V-set domain containing
- B7 family
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprogrammed cell death 1 ligand 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-11-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- B7 family
- CD molecules
- Immunoglobulin like domain containing
- Receptor ligands
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameV-set immunoregulatory receptor
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Synonyms gene
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Synonyms gene name
- chromosome 10 open reading frame 54
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-10-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- B7 family
- V-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameH1.9 linker histone, pseudogene
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Synonyms gene
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Synonyms gene name
- histone linker H1 domain, spermatid-specific 1
- histone linker H1 domain, spermatid-specific 1 (pseudogene)
- H1.9 linker histone (pseudogene)
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Synonyms
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GenBank acession
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Locus
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Discovery year2005-12-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- H1 histones
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameHERV-H LTR-associating 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-09-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- V-set domain containing
- B7 family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namerelaxin 1
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Synonyms gene name
- relaxin 1 (H1)
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Synonyms
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Synonyms name
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Classification
- Neuropeptides
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameH1.8 linker histone
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Synonyms gene
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Synonyms gene name
- H1 histone family, member O, oocyte-specific
- H1 histone family member O oocyte specific
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GenBank acession
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Locus
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Discovery year2003-05-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- H1 histones
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRNY4 pseudogene 2
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Synonyms gene name
- RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
- RNA, Ro-associated Y4 pseudogene 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-08-25
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Entrez gene record
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RefSeq identity
Gene info
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Identity
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Gene
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Long gene nameleucine rich repeat containing 23
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-01-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameectonucleotide pyrophosphatase/phosphodiesterase 2
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-08-10
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Entrez gene record
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Pubmed identfication
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Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
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VEGA ID