Fetuin A/AHSG

• Catalog number
  E21-425
• Price
  Please ask
• Size
  10ug

• Shipping_Temperature
  Ambient
• Product_State
  Lyophilized
• Formulation_Description
  Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.
• Storage
  Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Reconstitution
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Background
  α-2-HS Glycoprotein (AHSG) is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the Cystatin family of proteases inhibitors. It is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. AHSG is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. In addition, AHSG may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages. ASHG blocks TGF-beta-dependent signaling in osteoblastic cells.
• Alternative Names
  Alpha-2-HS-Glycoprotein; Alpha-2-Z-Globulin; Ba-Alpha-2-Glycoprotein; Fetuin-A; AHSG; FETUA
• Expression system
  Human cells

• Gene target
  Fetuin   A/AHSG  
• Gene symbol
  AHSG
• Short name
  Fetuin A/AHSG
• Species
  Human
• Alternative name
  Fetuin A/alpha-2-HS-glycoprotein
• Alternative to gene target
  alpha-2-HS-glycoprotein, A2HS and AHS and FETUA and HSGA, AHSG and IDBG-68916 and ENSG00000145192 and 197, kinase inhibitor activity, Extracellular, Ahsg and IDBG-148706 and ENSMUSG00000022868 and 11625, AHSG and IDBG-634683 and ENSBTAG00000000522 and 280988

Gene info

• Identity
  HGNC:349
• Gene
  AHSG
• Long gene name
  alpha 2-HS glycoprotein
• Synonyms
  • FETUA
  • A2HS
  • HSGA
• Synonyms name
  • fetuin A
• GenBank acession
  • D67013
  • M16961
• Locus
  3q27.3
• Discovery year
  1986-01-01
• Entrez gene record
  197
• Pubmed identfication
  • 9322749
  • 7736783
• RefSeq identity
  • NM_001622
• Classification
  • Cystatins, type 4
• VEGA ID
  OTTHUMG00000156605

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