beta-NGF/β-Nerve Growth Factor/β-NGF
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Catalog number
E21-I51
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Price
Please ask
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Size
10ug
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Shipping_Temperature
Ambient
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Product_State
Lyophilized
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Formulation_Description
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.0.
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Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Reconstitution
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Endotoxin
Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
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Background
Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits α, β, and γ; it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90% sequence similarity with mouse protein and shows cross-species reactivity.
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Alternative Names
Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB
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Expression system
Human cells
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Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
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Gene target
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Gene symbol
NGF, NGF-AS1
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Short name
beta-NGF/β-Nerve Growth Factor/β-NGF
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Species
Human
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Alternative name
b-nerve growth factor (beta polypeptide)/β-Nerve Growth Factor/β-nerve growth factor (beta polypeptide)
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Alternative to gene target
nerve growth factor (beta polypeptide), Beta-NGF and HSAN5 and NGFB, NGF and IDBG-101347 and ENSG00000134259 and 4803, growth factor activity, Extracellular, Ngf and IDBG-180362 and ENSMUSG00000027859 and 18049, NGF and IDBG-648895 and ENSBTAG00000007446 and 281350
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Tissue
nerve
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Gene info
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Identity
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Gene
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Long gene name
nerve growth factor
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Synonyms gene
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Synonyms gene name
- nerve growth factor (beta polypeptide)
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Locus
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Discovery year
2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene name
NGF antisense RNA 1
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Synonyms
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Locus
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Discovery year
2018-06-08
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Pubmed identfication
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Classification
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