Recombinant Rat Interleukin 25 / IL25 / IL17E Protein (Fc tag) 50µg

• Catalog number
  PKSR030327-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  IL25
• Activity
  Measured by its binding ability in a functional ELISA.Immobilized mouse IL17BR-His at 10 μg/mL (100 μl/well) can bind rat Fc-IL25. The EC50 of rat Fc-IL25 is 0.12-0.27 μg/mL.
• Sequence
  Val17-Ala169
• Fusion tag
  N-Fc
• Accession
  D3ZLB1
• ExpressedHost
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 85 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  46.1 kDa
• AP Mol Mass
  49 KDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)–activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided.
• Technical Data
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Interleukin   IL25   IL17E   Protein   tag   50µg  
• Gene symbol
  IL25, MYDGF
• Short name
  Recombinant Interleukin 25 / IL25 / IL17E Protein (Fc tag) 50µg
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  Rat
• Label
  Fc Tag
• Species
  Rat, Rats
• Alternative name
  Rec. Rat Interleukin 25 / interleukin 25 / IL17E Protein (fragment c detection labelled) 50µg
• Alternative technique
  rec
• Alternative to gene target
  interleukin 25, IL25 and IDBG-3218 and ENSG00000166090 and 64806, interleukin-17E receptor binding, Extracellular, Il25 and IDBG-162540 and ENSMUSG00000040770 and 140806, IL25 and IDBG-645820 and ENSBTAG00000009701 and 526816

Gene info

• Identity
  HGNC:13765
• Gene
  IL25
• Long gene name
  interleukin 25
• Synonyms gene
  • IL17E
• Synonyms gene name
  • interleukin 17E
• Synonyms
  • IL-25
  • IL-17E
• GenBank acession
  • AF305200
• Locus
  14q11.2
• Discovery year
  2001-01-26
• Pubmed identfication
  • 11058597
  • 11754819
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000028749

Gene info

• Identity
  HGNC:16948
• Gene
  MYDGF
• Long gene name
  myeloid derived growth factor
• Synonyms gene
  • IL27
  • IL27w
  • C19orf10
• Synonyms gene name
  • interleukin 27 working designation
  • chromosome 19 open reading frame 10
• Synonyms
  • R33729_1
  • IL25
  • SF20
  • IL-25
  • IL-27
• GenBank acession
  • AF282264
• Locus
  19p13.3
• Discovery year
  2002-04-03
• Entrez gene record
  56005
• Pubmed identfication
  • 17362502
  • 21128247
  • 25581518
• RefSeq identity
  • NM_019107
• VEGA ID
  OTTHUMG00000182039

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products