Recombinant Rat IL6 / Interleukin-6 Protein 100µg

• Catalog number
  PKSR030420-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  IL6
• Activity
  Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells.The ED50 for this effect is typically 1-6 ng/ml.
• Sequence
  Phe25-Thr211
• Fusion tag
  NA
• Accession
  NA
• ExpressedHost
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
• Purity
  > 90 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  21.9 kDa
• AP Mol Mass
  22 KDa
• Formulation
  Lyophilized from sterile 40% acetonitrile, 0.1% TFA
• Background
  Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Technical Data
• Gene
  Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. Recombinant, rec. E. coli interleukin-6 for cell culture or antibody production.
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  IL6   Interleukin-6   Protein   100µg  
• Gene symbol
  IL6-AS1, IL6, CEBPD
• Short name
  Recombinant IL6 / Interleukin-6 Protein 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  Rat
• Species
  Rat, Rats
• Alternative name
  Rec. Rat interleukin 6 (interferon, beta 2) / Interleukin-6 Protein 100µg
• Alternative technique
  rec
• Alternative to gene target
  interleukin 6 (interferon, beta 2), BSF2 and HGF and HSF and IFNB2 and IL-6, IL6 and IDBG-9462 and ENSG00000136244 and 3569, growth factor activity, Extracellular, Il6 and IDBG-144970 and ENSMUSG00000025746 and 16193, IL6 and IDBG-630280 and ENSBTAG00000014921 and 280826

Gene info

• Identity
  HGNC:40301
• Gene
  IL6-AS1
• Long gene name
  IL6 antisense RNA 1
• Locus
  7p15.3
• Discovery year
  2019-08-14
• Entrez gene record
  541472
• RefSeq identity
  • NR_131935
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:6018
• Gene
  IL6
• Long gene name
  interleukin 6
• Synonyms gene
  • IFNB2
• Synonyms gene name
  • interleukin 6 (interferon, beta 2)
• Synonyms
  • IL-6
  • BSF2
  • HGF
  • HSF
• Synonyms name
  • interferon, beta 2
• GenBank acession
  • M18403
• Locus
  7p15.3
• Discovery year
  1986-01-01
• Entrez gene record
  3569
• Pubmed identfication
  • 3294161
• RefSeq identity
  • NM_000600
• Classification
  • Interleukins
  • Interferons
  • Interleukin 6 type cytokine family
• VEGA ID
  OTTHUMG00000023178

Gene info

• Identity
  HGNC:1835
• Gene
  CEBPD
• Long gene name
  CCAAT enhancer binding protein delta
• Synonyms gene name
  • CCAAT/enhancer binding protein (C/EBP), delta
  • CCAAT/enhancer binding protein delta
• Synonyms
  • CRP3
  • CELF
  • C/EBP-delta
  • NF-IL6-beta
• Locus
  8q11.21
• Discovery year
  1992-06-24
• Entrez gene record
  1052
• Pubmed identfication
  • 1840554
  • 1884998
• RefSeq identity
  • NM_005195
• Classification
  • Basic leucine zipper proteins
  • CCAAT/enhancer binding proteins
• VEGA ID
  OTTHUMG00000162290

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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