Recombinant Rat IL23R / IL23 Receptor Protein (Fc tag) 50µg

• Catalog number
  PKSR030186-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  IL23R
• Activity
  Measured by its ability to bind recombinant mouse IL12Bh (m)+mIL23Ah in a functional ELISA.
• Sequence
  Met1-Asp367
• Fusion tag
  C-Fc
• Accession
  NA
• ExpressedHost
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  (75.1+16.6) as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  69.4 kDa
• AP Mol Mass
  69.4 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.
• Technical Data
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  IL23R   IL23   Receptor   Protein   tag   50µg  
• Gene symbol
  IL23R
• Short name
  Recombinant IL23R / IL23 Receptor Protein (Fc tag) 50µg
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  Rat
• Label
  Fc Tag
• Species
  Rat, Rats
• Alternative name
  Rec. Rat interleukin 23 receptor / IL23 Receptor Protein (fragment c detection labelled) 50µg
• Alternative technique
  rec
• Alternative to gene target
  interleukin 23 receptor, IL23R and IDBG-99558 and ENSG00000162594 and 149233, interleukin-23 receptor activity, multiple, Il23r and IDBG-154001 and ENSMUSG00000049093 and 209590, BT.48219 and IDBG-638122 and ENSBTAG00000014983 and 614367

Gene info

• Identity
  HGNC:19100
• Gene
  IL23R
• Long gene name
  interleukin 23 receptor
• Synonyms
  • IL-23R
• GenBank acession
  • AF461422
• Locus
  1p31.3
• Discovery year
  2004-10-18
• Entrez gene record
  149233
• Pubmed identfication
  • 12023369
• RefSeq identity
  • NM_144701
• VEGA ID
  OTTHUMG00000009092

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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