Recombinant Rat IL13RA2 / IL13R Protein (His tag) 200µg
-
Catalog number
PKSR030320-200µg
-
Price
Please ask
-
Size
200µg
-
-
Synonym
IL13RA2
-
Activity
Measured by its ability to inhibit IL13-dependent proliferation of TF-1 human erythroleukemic cells.The ED50 for this effect is typically 0.005-0.03 μg/mL.
-
Sequence
Met1-Lys336
-
Fusion tag
C-His
-
Accession
Q8VHK6
-
ExpressedHost
HEK293 Cells
-
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
-
Purity
> 85 % as determined by SDS-PAGE
-
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
-
Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Mol Mass
37.9 kDa
-
AP Mol Mass
44 KDa
-
Formulation
Lyophilized from sterile PBS, pH 7.4
-
Background
Interleukin-13 receptor subunit alpha-2 (IL13RA2/IL-13RA2) is also known as also known as cluster of differentiation 213A2 (CD213A2), IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, and IL-13RA2. The IL13RA2 is often overexpressed in brain tumors, making Il13ra2 one of the vaccine targets for immunotherapy of glioma. IL13RA2/IL-13RA2 is a cancer-associated receptor that is present in greater than 80% of High Grade Astrocytomas (HGA) and has recently been recognized as a cytokine that predisposes breast cancer cells to metastasize. Expression of IL13Rα2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to ligands present in fetal bovine serum in the medium. None of the malignant glioma cell lines cultivated in vitro and tested to date exhibited the IL13Rα2 receptor. A recombinant virus (R5111) enters cells via its interaction with the IL13Rα2 receptor in a manner that cannot be differentiated from the interaction of wild-type virus with its receptors.
-
-
Conjugation
histidine
-
About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
-
Latin name
Rattus norvegicus
-
Source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
IL13RA2
-
Short name
Recombinant IL13RA2 / IL13R Protein (His tag) 200µg
-
Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
-
Host
Rat
-
Label
His
-
Species
Rat, Rats
-
Alternative name
Rec. Rat interleukin 13 receptor, a 2 / IL13R Protein (histidine detection labelled) 200µg
-
Alternative technique
rec
-
Alternative to gene target
interleukin 13 receptor, alpha 2, CD213A2 and CT19 and IL-13R and IL13BP, IL13RA2 and IDBG-82958 and ENSG00000123496 and 3598, protein binding, Extracellular, Il13ra2 and IDBG-177428 and ENSMUSG00000031289 and 16165, IL13RA2 and IDBG-631325 and ENSBTAG00000020022 and 616008
-
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
