Recombinant Rat HER3 / ErbB3 Protein (His tag) 100µg
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Catalog number
PKSR030358-100µg
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Price
Please ask
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Size
100µg
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Synonym
ERBB3
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Activity
Measured by its binding ability in a functional ELISA. Immobilized rat ERBB3-His at 10 μg/ml (100 μl/well) can bind biotinylated human NRG1 , The EC50 of biotinylated human NRG1 is 1.1-2.6 μg/ml.
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Sequence
Met1-His641
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Fusion tag
C-His
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Accession
Q3MHC0
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ExpressedHost
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
> 95 % as determined by SDS-PAGE
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Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
69.9 kDa
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AP Mol Mass
112 KDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Background
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
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Conjugation
histidine
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About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin name
Rattus norvegicus
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
ERBB3
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Short name
Recombinant HER3 / ErbB3 Protein (His tag) 100µg
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Host
Rat
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Label
His
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Species
Rat, Rats
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Alternative name
Rec. Rat HER3 / v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Protein (histidine detection labelled) 100µg
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Alternative technique
rec
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Alternative to gene target
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), c-erbB-3 and c-erbB3 and ErbB-3 and erbB3-S and HER3 and LCCS2 and MDA-BF-1 and p180-ErbB3 and p45-sErbB3 and p85-sErbB3, ERBB3 and IDBG-39824 and ENSG00000065361 and 2065, transferase activity, Extracellular, Erbb3 and IDBG-197943 and ENSMUSG00000018166 and 13867, ERBB3 and IDBG-636302 and ENSBTAG00000010444 and 785655
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Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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