Recombinant Rat CLPS / Colipase Protein (His Tag)

• Catalog number
  PKSR030146-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  CLPS;Colipase
• Activity
  NA
• Sequence
  Met1-Gln112
• Fusion tag
  C-His
• Accession
  NP_037271.1
• ExpressedHost
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 95 % as determined by SDS-PAGE.
• Endotoxin
  < 1.0 EU per μg protein as determined by the LAL method.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  11.9 kDa
• AP Mol Mass
  11.9 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural analogies have been recognised between a developmental protein, the pancreatic lipase C-terminal domain, the N-terminal domains of lipoxygenases and the C-terminal domain of alpha-toxin. Colipase can only be detected in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Colipase allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Colipase is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilising as active conformation and considerably increasing the overall hydrophobic binding site.
• Technical data
• Conjugation
  histidine
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CLPS   Colipase   Protein   His   Tag  
• Gene symbol
  CLPS
• Short name
  Recombinant CLPS / Colipase Protein (His Tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  Rat
• Label
  His
• Species
  Rat, Rats
• Alternative name
  Rec. Rat CLPS / Colipase Protein (histidine detection labelled)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:2085
• Gene
  CLPS
• Long gene name
  colipase
• Synonyms gene name
  • colipase, pancreatic
• Synonyms name
  • pancreatic colipase
• Locus
  6p21.31
• Discovery year
  1990-10-05
• Entrez gene record
  1208
• Pubmed identfication
  • 2045105
• RefSeq identity
  • NM_001832
• VEGA ID
  OTTHUMG00000014578

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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