Recombinant Rat CD70 / CD27L / TNFSF7 Protein (His Tag) 50µg

• Catalog number
  PKSR030431-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  CD70
• Activity
  1.Measured by its binding ability in a functional ELISA.2.Immobilized rat His-CD70 at 10μg/mL (100μL/well) can bind mouse CD27-Fch , the EC50 of mouse CD27-Fch is 10-50ng/mL.
• Sequence
  Gln46-Pro195
• Fusion tag
  N-His
• Accession
  NP_001100348
• ExpressedHost
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
• Purity
  > 90 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  18.9 kDa
• AP Mol Mass
  28 KDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.Immune CheckpointImmune Checkpoint ProteinsImmune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Technical Data
• Conjugation
  histidine
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD70   CD27L   TNFSF7   Protein   His   Tag   50µg  
• Gene symbol
  CD70
• Short name
  Recombinant CD70 / CD27L / TNFSF7 Protein (His Tag) 50µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  Rat
• Label
  His
• Species
  Rat, Rats
• Alternative name
  Rec. Rat CD70 molecule / CD27L / TNFSF7 Protein (histidine detection labelled) 50µg
• Alternative technique
  rec
• Alternative to gene target
  CD70 molecule, CD27L and CD27LG and TNFSF7, CD70 and IDBG-21699 and ENSG00000125726 and 970, protein binding, Extracellular, Cd70 and IDBG-193725 and ENSMUSG00000019489 and 21948, CD70 and IDBG-643945 and ENSBTAG00000009752 and 522074

Gene info

• Identity
  HGNC:11937
• Gene
  CD70
• Long gene name
  CD70 molecule
• Synonyms gene
  • CD27LG
  • TNFSF7
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 7
• Synonyms
  • CD27L
• GenBank acession
  • L08096
• Locus
  19p13.3
• Discovery year
  1993-11-08
• Entrez gene record
  970
• Pubmed identfication
  • 8387892
  • 8120384
• Classification
  • CD molecules
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000181834

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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