Recombinant Rat ALK-1 / ACVRL1 Protein (His & Fc tag)

• Catalog number
  PKSR030416-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  R3;R-3;SETHKIR;MGC91691;Acvrl1
• Activity
  Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953.The ED50 for this effect is typically 40-200 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.
• Sequence
  Met 1-Ala 118
• Fusion tag
  His & Fc tag
• Accession
  NP_071886.1
• ExpressedHost
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 90 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  38.7 kDa
• AP Mol Mass
  50-55 KDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
• Technical data
• Conjugation
  histidine
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  ALK-1   ACVRL1   Protein   His   tag  
• Gene symbol
  ALK, ACVRL1, ENPP7, SLPI, TGFBR1, BMPR2, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1
• Short name
  Recombinant ALK-1 / ACVRL1 Protein (His & Fc tag)
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  Rat
• Label
  His
• Species
  Rat, Rats
• Alternative name
  Rec. Rat anaplastic lymphoma receptor tyrosine kinase-1 / activin A receptor classification II-like 1 Protein (histidine & fragment c detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  activin A receptor type II-like 1, ACVRLK1 and ALK-1 and ALK1 and HHT and HHT2 and ORW2 and SKR3 and TSR-I, ACVRL1 and IDBG-33826 and ENSG00000139567 and 102723650,94, transforming growth factor beta receptor activity, Cell surfaces, Acvrl1 and IDBG-185502 and ENSMUSG00000000530 and 11482, BT.28710 and IDBG-632173 and ENSBTAG00000013843 and 534536

Gene info

• Identity
  HGNC:427
• Gene
  ALK
• Long gene name
  ALK receptor tyrosine kinase
• Synonyms gene name
  • anaplastic lymphoma kinase (Ki-1)
  • anaplastic lymphoma receptor tyrosine kinase
• Synonyms
  • CD246
  • ALK1
• GenBank acession
  • D45915
• Locus
  2p23.2-p23.1
• Discovery year
  1993-08-24
• Entrez gene record
  238
• Pubmed identfication
  • 8122112
• RefSeq identity
  • NM_004304
• Classification
  • Receptor tyrosine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000152034
• Locus Specific Databases
  • LRG_488

Gene info

• Identity
  HGNC:175
• Gene
  ACVRL1
• Long gene name
  activin A receptor like type 1
• Synonyms gene
  • ACVRLK1
  • ORW2
• Synonyms gene name
  • activin A receptor type II-like 1
  • activin A receptor type IL
• Synonyms
  • HHT2
  • ALK1
  • HHT
• Synonyms name
  • activin receptor-like kinase 1
• GenBank acession
  • L17075
• Locus
  12q13.13
• Discovery year
  1994-12-12
• Entrez gene record
  94
• Pubmed identfication
  • 8397373
  • 8640225
  • 22718755
• RefSeq identity
  • NM_000020
• Classification
  • Type 1 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000169507
• Locus Specific Databases
  • Hereditary Hemorrhagic Telangiectasia (HHT) Mutation Database
  • LRG_543

Gene info

• Identity
  HGNC:23764
• Gene
  ENPP7
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 7
• Synonyms
  • alk-SMase
  • NPP7
• Synonyms name
  • alkaline sphingomyelinase
• GenBank acession
  • AY230663
• Locus
  17q25.3
• Discovery year
  2004-04-29
• Entrez gene record
  339221
• Pubmed identfication
  • 12885774
• RefSeq identity
  • NM_178543
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
• VEGA ID
  OTTHUMG00000177462

Gene info

• Identity
  HGNC:11092
• Gene
  SLPI
• Long gene name
  secretory leukocyte peptidase inhibitor
• Synonyms gene name
  • secretory leukocyte protease inhibitor (antileukoproteinase)
• Synonyms
  • HUSI-I
  • ALK1
  • ALP
  • BLPI
  • HUSI
  • WAP4
  • WFDC4
• Synonyms name
  • antileukoproteinase
• GenBank acession
  • X04502
• Locus
  20q13.12
• Discovery year
  1998-04-24
• Entrez gene record
  6590
• Pubmed identfication
  • 3640338
  • 12206714
• Classification
  • WAP four-disulfide core domain containing
• VEGA ID
  OTTHUMG00000033075

Gene info

• Identity
  HGNC:11772
• Gene
  TGFBR1
• Long gene name
  transforming growth factor beta receptor 1
• Synonyms gene
  • MSSE
  • ESS1
• Synonyms gene name
  • multiple self-healing squamous epithelioma
  • transforming growth factor beta receptor I
• Synonyms
  • ALK-5
  • ACVRLK4
  • ALK5
  • TBRI
  • TBR-i
• Synonyms name
  • activin A receptor type II-like kinase, 53kDa
• Locus
  9q22.33
• Discovery year
  1993-09-30
• Entrez gene record
  7046
• Pubmed identfication
  • 1319842
  • 8530052
  • 21358634
• Classification
  • Type 1 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000020353
• Locus Specific Databases
  • LOVD - Center for Medical Genetics, Ghent, Belgium

Gene info

• Identity
  HGNC:1078
• Gene
  BMPR2
• Long gene name
  bone morphogenetic protein receptor type 2
• Synonyms gene
  • PPH1
• Synonyms gene name
  • primary pulmonary hypertension 1
  • bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • bone morphogenetic protein receptor type II
• Synonyms
  • BRK-3
  • T-ALK
  • BMPR3
  • BMPR-II
• GenBank acession
  • Z48923
• Locus
  2q33.1-q33.2
• Discovery year
  1997-03-19
• Entrez gene record
  659
• Pubmed identfication
  • 7791754
• RefSeq identity
  • NM_001204
• Classification
  • Type 2 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000133617
• Locus Specific Databases
  • LRG_712

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

Gene info

• Identity
  HGNC:50819
• Gene
  TRUND-NNN7-1
• Long gene name
  tRNA-undetermined (NNN) 7-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 7-1
• GenBank acession
  • HG984096
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482531
• Pubmed identfication
  • 18984615

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products