Recombinant Mouse Triggering Receptor Expressed on Myeloid Cells 2b/TREM-2b Protein(C-Fc)

• Catalog number
  PKSM041175-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  Triggering Receptor Expressed on Myeloid Cells 2b; Triggering receptor expressed on myeloid cells 2; TREM-2; Triggering receptor expressed on monocytes 2; Trem2; Trem2a; Trem2b; Trem2c; TREM-2b
• Activity
  NA
• Sequence
  Leu19-Pro168
• Fusion tag
  C-Fc
• Accession
  Q99NH8
• Expressed Host
  Human Cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  43.7 kDa
• AP Mol Mass
  60kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
• Background
  Triggering receptor expressed on myeloid cells-2 (TREM-2) is a cell surface receptor primarily expressed on macrophages, osteoclasts, microglia and dendritic cells. TREM-2 is one member of the TREM family, inhibiting the releasing of inflammatory mediators, so it is an important in vivo anti-inflammatory receptor. TREM-2 consists of an 18 aa signal sequence, a 153 aa extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. A soluble form of TREM-2 (TREM-2b) created by alternate splicing diverges at aa 161. TREM-2 transduces intracellular signals through the adaptor DAP12. After binding of TREM-2 with ligand, the TREM-2/DAP12 (dead-cell-activated-receptor-associated protein)-mediated signal transduction pathway causes a series of intracellular protein tyrosine phosphorylation reactions and enzymatic reactions, which then activate the myeloid cells and participate T cell responses.
• Technical data
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Triggering   Receptor   Expressed   Myeloid   Cells   2b/TREM-2b   Protein   C-Fc  
• Gene symbol
  TREM1, TREM2
• Short name
  Recombinant Mouse Triggering Receptor Expressed on Myeloid Cells 2b/TREM-2b Protein(C-Fc)
• Technique
  Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse Triggering Receptor Expressed on Myeloid Cells 2b/TREM-2b Protein(C-fragment c)
• Alternative technique
  rec, murine
• Tissue
  cells

Gene info

• Identity
  HGNC:17760
• Gene
  TREM1
• Long gene name
  triggering receptor expressed on myeloid cells 1
• Synonyms
  • TREM-1
  • CD354
• GenBank acession
  • AF196329
• Locus
  6p21.1
• Discovery year
  2002-08-09
• Entrez gene record
  54210
• Pubmed identfication
  • 11922939
  • 10799849
• RefSeq identity
  • NM_018643
• Classification
  • V-set domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000014674

Gene info

• Identity
  HGNC:17761
• Gene
  TREM2
• Long gene name
  triggering receptor expressed on myeloid cells 2
• Synonyms gene name
  • triggering receptor expressed on myeloid cells 2a
• Synonyms
  • TREM-2
  • Trem2a
  • Trem2b
  • Trem2c
• GenBank acession
  • AF213457
• Locus
  6p21.1
• Discovery year
  2002-08-09
• Entrez gene record
  54209
• Pubmed identfication
  • 10799849
  • 12080485
• RefSeq identity
  • NM_018965
• Classification
  • V-set domain containing
• VEGA ID
  OTTHUMG00000014671
• Locus Specific Databases
  • LRG_631

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products