Recombinant Mouse Tie2 / TEK Protein (aa 770-1122, His & GST tag) 50µg
-
Catalog number
PKSM040369-50µg
-
Price
Please ask
-
Size
50µg
-
-
Activity
1. No Kinase Activity2. Measured by its binding ability in a functional ELISA. Immobilized mouse TEK (aa 770-1122) at 2 μg/ml (100 μl/well) can bind human Ang2-Fc with a linear range of 0.25-2.0 μg/ml.
-
Synonym
AA517024;Cd202b;Hyk;STK1;Tie-2;Tie2
-
Sequence
Gln770-Ala1122
-
Fusion tag
N-His & GST
-
Accession
Q02858
-
Expressed Host
Baculovirus-Insect Cells
-
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
-
Purity
> 91 % as determined by SDS-PAGE
-
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
-
Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Mol Mass
68.2kDa
-
AP Mol Mass
68 kDa
-
Formulation
Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% gly
-
Background
TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
-
-
Conjugation
histidine
-
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin name
Mus musculus
-
Source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
MGST3, MIR770, TEK
-
Short name
Recombinant Mouse Tie2 / TEK Protein (aa 770-1122, His & GST tag) 50µg
-
Technique
Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
-
Host
mouse
-
Label
His
-
Species
Mouse, Mouses
-
Alternative name
Rec. Mouse Tie2 / TEK tyrosine kinase, endothelial Protein (aa 770-1122, histidine & GST detection labelled) 50µg
-
Alternative technique
rec, murine
-
Alternative to gene target
TEK tyrosine kinase, endothelial, CD202B and TIE-2 and TIE2 and VMCM and VMCM1, TEK and IDBG-55143 and ENSG00000120156 and 7010, transferase activity, Extracellular, Tek and IDBG-163684 and ENSMUSG00000006386 and 21687, TEK and IDBG-629912 and ENSBTAG00000020148 and 280939
-
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
microRNA 770
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year
2006-10-10
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products