Recombinant Mouse T-lymphocyte Activation Antigen CD80 Protein

• Catalog number
  PKSM040679-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80
• Activity
  Measured by its ability to bind recombinant mouse CD28 in a functional ELISA.
• Sequence
  Val38-Asn246
• Fusion tag
  C-6His
• Accession
  Q00609
• Expressed Host
  Human Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  24.6 kDa
• AP Mol Mass
  38-55 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
• Background
  Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. Mouse CD80 consists of an extracellular domain (ECD) with twoimmunoglobulin-like domains, transmembrane segment, and cytoplasmic domain. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.
• Technical data
• Description
  Antigens are peptides or recombinant or native dependent on the production method.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  T-lymphocyte   Activation   CD80   Protein  
• Gene symbol
  CD80
• Short name
  Recombinant Mouse T-lymphocyte Activation Antigen CD80 Protein
• Technique
  Recombinant, activation, antigen, Mouse, antigenes, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse T-lymphocyte Activation protein CD80 molecule Protein
• Alternative technique
  rec, antigenes, murine
• Alternative to gene target
  CD80 molecule, B7 and B7-1 and B7.1 and BB1 and CD28LG and CD28LG1 and LAB7, CD80 and IDBG-51287 and ENSG00000121594 and 941, coreceptor activity, Cell surfaces, Cd80 and IDBG-160288 and ENSMUSG00000075122 and 12519, BT.27986 and IDBG-632750 and ENSBTAG00000018059 and 407131
• Tissue
  lymphocyte

Gene info

• Identity
  HGNC:1700
• Gene
  CD80
• Long gene name
  CD80 molecule
• Synonyms gene
  • CD28LG
  • CD28LG1
• Synonyms gene name
  • CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
  • CD80 molecule
• Synonyms
  • B7.1
  • B7-1
• Synonyms name
  • B-lymphocyte activation antigen B7
• Locus
  3q13.33
• Discovery year
  1993-12-14
• Entrez gene record
  941
• Pubmed identfication
  • 1370389
• RefSeq identity
  • NM_005191
• Classification
  • B7 family
  • CD molecules
  • C2-set domain containing
  • V-set domain containing
• VEGA ID
  OTTHUMG00000159419

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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