Recombinant Mouse Serpin D1/Heparin Cofactor II/HCF2 Protein(C-6His) 50µg

• Catalog number
  PKSM041140-50µg
• Price
  Please ask
• Size
  50µg

• Activity
  NA
• Synonym
  Heparin cofactor 2; Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; Serpin D1
• Sequence
  Glu24-Ser478
• Fusion tag
  C-6His
• Accession
  P49182
• Expressed Host
  Human Cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  53.1 kDa
• AP Mol Mass
  70-90 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of 20mM HEPES,150mM NaCl,pH7.4.
• Background
  SerpinD1, also known as heparin cofactor II(HC-II), is a member of Serpin superfamily of the serine proteinase inhibitors. It is a single chain glycoprotein with a size of 66.5 kDa and is secreted from hepatocytes. HC-II acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. It has been suggested that HC-II is a predictor of decreased atherosclerosis in the elderly and protective against atherosclerosis in mice. HCII can used as a predictive biomarker and therapeutic target for atherosclerosis.
• Technical data
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Serpin   D1/Heparin   Cofactor   II/HCF2   Protein   C-6His   50µg  
• Gene symbol
  SERPIND1
• Short name
  Recombinant Mouse Serpin D1/Heparin Cofactor II/HCF2 Protein(C-6His) 50µg
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse Serpin D1/Heparin Cofactor II/HCF2 Protein(C-6His) 50µg
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:4838
• Gene
  SERPIND1
• Long gene name
  serpin family D member 1
• Synonyms gene
  • HCF2
• Synonyms gene name
  • serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
  • serpin peptidase inhibitor, clade D (heparin cofactor), member 1
• Synonyms
  • HC-II
  • HLS2
  • HC2
  • D22S673
• Synonyms name
  • heparin cofactor II
  • heparin cofactor 2
• GenBank acession
  • M12849
• Locus
  22q11.21
• Discovery year
  1988-05-31
• Entrez gene record
  3053
• Pubmed identfication
  • 1671335
  • 24172014
• RefSeq identity
  • NM_000185
• Classification
  • Serpin peptidase inhibitors
• VEGA ID
  OTTHUMG00000150755
• Locus Specific Databases
  • LRG_594

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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